ArticleThe Journal of physiology1997
Hypoxia inhibits the recombinant alpha 1C subunit of the human cardiac L-type Ca2+ channel.
Article in The Journal of physiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Incidence and outcomes of transient new-onset atrial fibrillation complicating acute coronary syndromes: results from a systematic review and meta-analysis.European heart journal. Cardiovascular pharmacotherapy · 2025Pooled it
- The psychiatric risk gene CACNA1C encodes distinct full-length isoforms in human brain, heart and aorta.Molecular psychiatry · 2026Article
- Sleep-Disordered Breathing Destabilizes Ventricular Repolarization.medRxiv : the preprint server for health sciences · 2024Article
- Acute oxygen sensing by vascular smooth muscle cells.Frontiers in physiology · 2023Review
- Metabolic inhibition reduces cardiac L-type Ca2+ channel current due to acidification caused by ATP hydrolysis.PloS one · 2017Article
- Evidence for redox sensing by a human cardiac calcium channel.Scientific reports · 2016Article
- Altered Calcium Handling and Ventricular Arrhythmias in Acute Ischemia.Clinical Medicine Insights. Cardiology · 2016Review
- Mechanisms underlying the modulation of L-type Ca2+ channel by hydrogen peroxide in guinea pig ventricular myocytes.The journal of physiological sciences : JPS · 2013Article
- Aggravation of myocardial dysfunction by injurious mechanical ventilation in LPS-induced pneumonia in rats.Respiratory research · 2013Article
- TRP channels as sensors of oxygen availability.Pflugers Archiv : European journal of physiology · 2013Review
- Hypoxic regulation of cardiac Ca2+ channel: possible role of haem oxygenase.The Journal of physiology · 2012Article
- L-type calcium channel as a cardiac oxygen sensor.Annals of the New York Academy of Sciences · 2010Article
- Contributions of ion channel currents to ventricular action potential changes and induction of early afterdepolarizations during acute hypoxia.Circulation research · 2009Article
- Ion channels as effectors in carbon monoxide signaling.Communicative & integrative biology · 2009Article
- Carbon monoxide inhibits L-type Ca2+ channels via redox modulation of key cysteine residues by mitochondrial reactive oxygen species.The Journal of biological chemistry · 2008Article
- Acute hypoxia differentially regulates K(+) channels. Implications with respect to cardiac arrhythmia.European biophysics journal : EBJ · 2005Review
- Differential regulation of the slow and rapid components of guinea-pig cardiac delayed rectifier K+ channels by hypoxia.The Journal of physiology · 2004Article
- NADPH oxidase is an O2 sensor in airway chemoreceptors: evidence from K+ current modulation in wild-type and oxidase-deficient mice.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Clotrimazole inhibits the recombinant human cardiac L-type Ca2+ channel alpha 1C subunit.British journal of pharmacology · 2000Article
- Acid-evoked quantal catecholamine secretion from rat phaeochromocytoma cells and its interaction with hypoxia-evoked secretion.The Journal of physiology · 1999Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
1. Whole-cell patch clamp recordings were used to investigate the effects of hypoxia on recombinant human L-type Ca2+ channel alpha 1C subunits stably expressed in human embryonic kidney (HEK 293) cells. 2. Ca2+ channel currents were reversibly inhibited by hypoxia (PO2 < 90 mmHg). The degree of inhibition depended on the charge carrier used, Ca2+ currents being more O2 sensitive than Ba2+ currents. 3. Hypoxic inhibition of Ca2+ channel currents was more pronounced at lower activating membrane potentials (< or = +30 mV), and was associated with a slowing of activation kinetics. Current inactivation and deactivation were unaffected by hypoxia. 4. Since hypoxia similarly regulates native L-type Ca2+ channels in vascular smooth muscle cells, our results suggest that hypoxic regulation of L-type Ca2+ channels arises from modification of structural features of the alpha 1 subunit common to cardiac and smooth muscle L-type channels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.