ReviewBrain pathology (Zurich, Switzerland)1997
The molecular biology of ependymomas.
Review in Brain pathology (Zurich, Switzerland), 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.
- Childhood ependymoma: a systematic review of treatment options and strategies.Paediatric drugs · 2003Pooled it
- Benign Spinal Tumors.Advances in experimental medicine and biology · 2023Article
- Mutation profiling of anaplastic ependymoma grade III by Ion Proton next generation DNA sequencing.F1000Research · 2019Article
- Article
- Transcriptomic analysis in pediatric spinal ependymoma reveals distinct molecular signatures.Oncotarget · 2017Article
- Malignant Transformation of Grade II Ependymoma in a 2-Year-Old Child: Case Report.Journal of neurological surgery reports · 2015Article
- Subependymoma with extensive microcystic transformation: a case report.International journal of clinical and experimental pathology · 2015Article
- Study of chromosome 9q gain, Notch pathway regulators and Tenascin-C in ependymomas.Journal of neuro-oncology · 2014Article
- The fine structure of ependymomas.CNS oncology · 2014Review
- A deletion causing NF2 exon 9 skipping is associated with familial autosomal dominant intramedullary ependymoma.Neuro-oncology · 2014Article
- Spinal cord tumours: advances in genetics and their implications for treatment.Nature reviews. Neurology · 2013Review
- Increased expression of tumor-associated antigens in pediatric and adult ependymomas: implication for vaccine therapy.Journal of neuro-oncology · 2013Article
- Anaplastic ependymoma simulating glioblastoma in the cerebrum of an adult.Brain tumor pathology · 2012Article
- Molecular genetics of ependymoma.Chinese journal of cancer · 2011Review
- Article
- Adult intracranial WHO grade II ependymomas: long-term outcome and prognostic factor analysis in a series of 114 patients.Neuro-oncology · 2010Article
- Specific chromosomal imbalances as detected by array CGH in ependymomas in association with tumor location, histological subtype and grade.Journal of neuro-oncology · 2010Article
- Primary myxopapillary ependymoma of the cerebellopontine angle: report of a case.Neurosurgical review · 2009Article
- Predicting which children are at risk for ependymoma relapse.Journal of neuro-oncology · 2006Article
- Molecular pathogenesis of childhood brain tumors.Journal of neuro-oncology · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracranial ependymomas are the third most common primary brain tumor in the pediatric population. Although an anaplastic variant is recognized, numerous studies examining the prognostic implications of histological features, such as necrosis, endothelial proliferation and mitoses, have yielded contradictory results. In order to improve outcome prediction in affected patients and to refine therapeutic decision-making, there is a strong need for identifying relevant biological correlates of tumor behavior. The molecular biology of tumors is a rapidly expanding field and includes investigations into cytogenetics, oncogenes, growth factors, growth factor receptors, hormonal receptors, proliferation markers, apoptosis, cell cycle genes and cell adhesion molecules, as well as factors potentially related to therapeutic resistance, such as the multidrug resistance gene. The molecular biology of astrocytic tumors in adults has been the subject of many studies; however, relatively few studies have been focused on ependymomas. Herein we review potential oncological markers in ependymomas that have been identified to date and highlight the limitations of our current knowledge as a basis for defining areas for future investigation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.