ReviewBrain pathology (Zurich, Switzerland)1997
Primitive neuroectodermal tumors of the central nervous system.
Review in Brain pathology (Zurich, Switzerland), 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 105 citations in OpenAlex.
- Medulloblastomas, CNS embryonal tumors, and cerebellar mutism syndrome: advances in care and future directions.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- Embryonal Tumors of the Central Nervous System with Multilayered Rosettes and Atypical Teratoid/Rhabdoid Tumors.Advances in experimental medicine and biology · 2023Article
- Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation.Acta neuropathologica communications · 2021Article
- MRI Features of Histologically Diagnosed Supratentorial Primitive Neuroectodermal Tumors and Pineoblastomas in Correlation with Molecular Diagnoses and Outcomes: A Report from the Children's Oncology Group ACNS0332 Trial.AJNR. American journal of neuroradiology · 2019Article
- The incidence of brainstem primitive neuroectodermal tumors of childhood based on SEER data.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
- Article
- Article
- Supratentorial primitive neuroectodermal tumors: a Canadian pediatric brain tumor consortium report.Journal of neuro-oncology · 2008Article
- Medulloblastoma: therapy and biologic considerations.Current neurology and neuroscience reports · 2006Review
- Cancerous stem cells can arise from pediatric brain tumors.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Are childhood and adult medulloblastomas different? A comparative study of clinicopathological features, proliferation index and apoptotic index.Journal of neuro-oncology · 2002Article
- Pleomorphic primitive neuroectodermal tumor with glial and neuronal differentiation: clinical, pathological, cultural, and chromosomal analysis of a case.Journal of neuro-oncology · 2002Article
- Article
- Semaphorin 3A-vascular endothelial growth factor-165 balance mediates migration and apoptosis of neural progenitor cells by the recruitment of shared receptor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Cytogenetic and histopathologic studies of congenital supratentorial primitive neuroectodermal tumors: a case report.Pathology oncology research : POR · 2001Article
- Differential expression of somatostatin receptors in medulloblastoma.Journal of neuro-oncology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Controversial issues relating to the pathobiology and classification of central nervous system primitive neuroectodermal tumors (PNETs) have plagued neuropathologists for more than 70 years. Hypotheses advanced in the mid-1920's have remained as fixed concepts in contemporary literature, largely consequent to repetitious support by a small number of neuropathologists despite a growing body of information discrediting these ideas from neuroembryologists, oncologists, neuroscientists and pathologists. Attention has largely focused upon PNETs arising in the cerebellum (commonly known as medulloblastomas ([MBs]), because about 80% of central nervous system (CNS) PNETs originate in this site. It has been asserted that the 20% which do not are biologically different, although most individuals agree that the histological features of PNETs that occur in different sites throughout the CNS are indistinguishable from those growing in the cerebellum. The historical aspects of this controversy are examined in the face of evidence that there is, in fact, a unique class of CNS tumors which should appropriately be regarded as primitive neuroectodermal in nature. Specifically, a number of different approaches to the problem have yielded data supporting this hypothesis. These approaches include the identification of patterns of expression among a variety of cellular antigens (demonstrated by the use of immunopathological techniques), molecular analyses of cell lines derived from these tumors, experimental production of PNETs and molecular genetic analyses. Differences of opinion among surgeons, oncologists and radiotherapists are typically resolved by conducting cooperative studies of patients with these tumors who are diagnosed and treated at multiple centers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.