ArticleProceedings of the National Academy of Sciences of the United States of America1997
Neuregulins stimulate the functional expression of Ca2+-activated K+ channels in developing chicken parasympathetic neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 35 citations in OpenAlex.
- Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons.Molecular psychiatry · 2015Article
- Neph1 regulates steady-state surface expression of Slo1 Ca(2+)-activated K(+) channels: different effects in embryonic neurons and podocytes.American journal of physiology. Cell physiology · 2009Article
- Neurotrophins and target interactions in the development and regulation of sympathetic neuron electrical and synaptic properties.Autonomic neuroscience : basic & clinical · 2009Review
- Neuregulin 1 in neural development, synaptic plasticity and schizophrenia.Nature reviews. Neuroscience · 2008Review
- Alternatively spliced C-terminal domains regulate the surface expression of large conductance calcium-activated potassium channels.Neuroscience · 2007Article
- The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia.BMC psychiatry · 2002Article
- beta -Neuregulin-1 is required for the in vivo development of functional Ca2+-activated K+ channels in parasympathetic neurons.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- dSLo interacting protein 1, a novel protein that interacts with large-conductance calcium-activated potassium channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The developmental expression of macroscopic Ca2+-activated K+ currents (IK[Ca]) in chicken ciliary ganglion (CG) neurons is dependent in part on trophic factors released from preganglionic nerve terminals. Neuregulins are expressed in the preganglionic neurons that innervate the chicken CG and are therefore plausible candidates for this activity. Application of 1 nM beta1-neuregulin peptide for 12 hr evokes a large (7- to 10-fold) increase in IK[Ca] in embryonic day 9 CG neurons, even in the presence of a translational inhibitor. A similar posttranslational effect is produced by high concentrations (10 nM) of epidermal growth factor and type alpha transforming growth factor but not by 10 nM alpha2-neuregulin peptide or by neurotrophins at 40 ng.ml-1. beta1-neuregulin treatment for 12 hr also confers Ca2+ sensitivity onto large-conductance (285 pS) K+ channels observed in inside-out patches. beta-Neuregulins have no effect on voltage-activated Ca2+ currents of CG neurons. These data support the hypothesis that beta-neuregulins mediate the trophic effects of preganglionic nerve terminals on the electrophysiological differentiation of developing CG neurons.
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