ArticleProceedings of the National Academy of Sciences of the United States of America1997
Major histocompatibility complex gene mapping in the amphibian Xenopus implies a primordial organization.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 87 citations in OpenAlex.
- Compact genomic architecture of the axolotl MHC region: setting the record straight.Immunogenetics · 2025Article
- Allele co-segregation and haplotype diversity of MHC IIβ genes in the small-spotted catshark Scyliorhinus canicula.Immunogenetics · 2025Article
- An Ancestral Major Histocompatibility Complex Organization in Cartilaginous Fish: Reconstructing MHC Origin and Evolution.Molecular biology and evolution · 2023Article
- Selection and demography drive range-wide patterns of MHC-DRB variation in mule deer.BMC ecology and evolution · 2022Article
- An Ancient, MHC-Linked, Nonclassical Class I Lineage in Cartilaginous Fish.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- TheAnimals : an open access journal from MDPI · 2019Article
- Inferring the "Primordial Immune Complex": Origins of MHC Class I and Antigen Receptors Revealed by Comparative Genomics.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Origin and evolution of the specialized forms of proteasomes involved in antigen presentation.Immunogenetics · 2019Review
- Adaptive tolerance to a pathogenic fungus drives major histocompatibility complex evolution in natural amphibian populations.Proceedings. Biological sciences · 2016Article
- Coevolution of MHC genes (LMP/TAP/class Ia, NKT-class Ib, NKp30-B7H6): lessons from cold-blooded vertebrates.Immunological reviews · 2015Review
- Characterisation of major histocompatibility complex class I genes at the fetal-maternal interface of marsupials.Immunogenetics · 2015Article
- Genomic organization of the crested ibis MHC provides new insight into ancestral avian MHC structure.Scientific reports · 2015Article
- Evolution by selection, recombination, and gene duplication in MHC class I genes of two Rhacophoridae species.BMC evolutionary biology · 2013Article
- Genetic diversity of MHC class I loci in six non-model frogs is shaped by positive selection and gene duplication.Heredity · 2012Article
- The hitchhiker's guide to Xenopus genetics.Genesis (New York, N.Y. : 2000) · 2012Review
- The tammar wallaby major histocompatibility complex shows evidence of past genomic instability.BMC genomics · 2011Article
- Primordial linkage of β2-microglobulin to the MHC.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Selection, trans-species polymorphism, and locus identification of major histocompatibility complex class IIβ alleles of New World ranid frogs.Immunogenetics · 2010Article
- MHC-linked and un-linked class I genes in the wallaby.BMC genomics · 2009Article
- Comparative and developmental study of the immune system in Xenopus.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
One of the most provocative recent discoveries in immunology was the description of a genetic linkage in the major histocompatibility complex (MHC) between structurally unrelated genes whose products are involved in processing and presentation of antigens for recognition by T lymphocytes. Genes encoding MHC class I molecules, which bind and present at the cell surface proteolytic fragments of cytosolic proteins, are linked to nonhomologous genes whose products are involved in the production and subsequent transfer of such fragments into the endoplasmic reticulum. In mammals, the class I presentation and processing genes are found in different regions of the MHC. To examine the evolutionary origins of this genetic association, linkage studies were carried out with Xenopus, an amphibian last sharing an ancestor with mammals over 350 million years ago. In contrast to mammals, the single copy Xenopus class I gene is located between the class II and III regions, speculated to be in close linkage with the processing and transport genes. In addition to suggesting a primordial organization of genes involved in class I antigen presentation, these linkage studies further provide insight into the origins of the MHC class III region and the phenomenon of class I gene instability in the mammalian MHC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.