ArticleArteriosclerosis, thrombosis, and vascular biology1997
In vivo transfer of lipoprotein(a) into human atherosclerotic carotid arterial intima.
Article in Arteriosclerosis, thrombosis, and vascular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality.JAMA · 2009 · on this mapPooled it
- Increased lipoprotein(a) levels independently predict a higher incidence of ventricular arrhythmias: A comprehensive retrospective cohort study.Heart rhythm O2 · 2025Article
- Lipoprotein(a): Just an Innocent Bystander in Arterial Hypertension?International journal of molecular sciences · 2023Review
- Elevated Lp(a) Levels Correlate with Severe and Multiple Coronary Artery Stenotic Lesions.Vascular health and risk management · 2023Article
- Lipoprotein (a) levels and vulnerable characteristics in nonculprit plaque in patients with acute coronary syndrome.International journal of cardiology. Heart & vasculature · 2022Article
- Article
- The Predictive Value of Lp(a) for Adverse Cardiovascular Event in ACS Patients With an Achieved LDL-C Target at Follow Up After PCI.Journal of cardiovascular translational research · 2022Article
- Potential Causality and Emerging Medical Therapies for Lipoprotein(a) and Its Associated Oxidized Phospholipids in Calcific Aortic Valve Stenosis.Circulation research · 2019Review
- Advances in lipid-lowering therapy through gene-silencing technologies.Nature reviews. Cardiology · 2018Review
- Article
- Lipoprotein (a) as a cause of cardiovascular disease: insights from epidemiology, genetics, and biology.Journal of lipid research · 2016Review
- Elevated lipoprotein(a) levels predict cardiovascular disease in type 2 diabetes mellitus: a 10-year prospective cohort study.The Korean journal of internal medicine · 2016Observational
- HyperLp(a)lipoproteinaemia: unmet need of diagnosis and treatment?Blood transfusion = Trasfusione del sangue · 2016Article
- Genetic risk factors for spontaneous intracerebral haemorrhage.Nature reviews. Neurology · 2016Review
- Lipoprotein (a), an independent cardiovascular risk marker.Clinical diabetes and endocrinology · 2016Review
- Coronary Artery Disease Severity and Cardiovascular Biomarkers in Patients with Peripheral Artery Disease.The International journal of angiology : official publication of the International College of Angiology, Inc · 2015Article
- New and emerging biomarkers in cardiovascular disease.Current diabetes reports · 2015Review
- Novel metabolic biomarkers of cardiovascular disease.Nature reviews. Endocrinology · 2014Review
- Carotid Intima-Media Thickness in Asymptomatic Subjects With Low Lipoprotein(a) Levels.Journal of clinical medicine research · 2012Article
- Lipoprotein(a) was an independent predictor for major coronary events in treated hypertensive men.Clinical cardiology · 2002Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to compare the atherogenic potential of lipoprotein(a) [Lp(a)] and LDL by measuring the intimal clearance of these two plasma lipoproteins in the atherosclerotic intima of the human carotid artery in vivo. Autologous 131I-Lp(a) and 125I-LDL were mixed and reinjected intravenously 3 hours before elective surgical removal of the arterial intima in four patients. The intimal clearance of Lp(a) and LDL was 229+/-48 and 405+/-127 nL/cm2 per hour, respectively (paired t test; P=.12). The mass accumulation of Lp(a) (114+/-32 ng/cm2 per hour) was on average one 15th that of LDL (paired t test; P=.06), mainly reflecting a low plasma concentration of Lp(a) compared with LDL in the human subjects studied. In accordance with our previous observation in rabbits, there was a positive association between the intimal clearance of LDL and that of Lp(a) (r=.97, P=.03). Accordingly, high plasma levels of Lp(a) may share with LDL the potential for causing lipid accumulation in the arterial intima in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.