ArticleJournal of clinical microbiology1997
Comparison of four molecular typing methods for evaluating genetic diversity among Candida albicans isolates from human immunodeficiency virus-positive patients with oral candidiasis.
Article in Journal of clinical microbiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 57 citations in OpenAlex.
- Random amplification of polymorphic DNA and microsatellite genotyping of pre- and posttreatment isolates of Candida spp. from human immunodeficiency virus-infected patients on different fluconazole regimens.Journal of clinical microbiology · 1998Trial
- Antimicrobial effect of para-alkoxyphenylcarbamic acid esters containing substituted N-phenylpiperazine moiety.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2013Article
- Comparison of Enzymatic Method Rapid Yeast Plus System with RFLP-PCR for Identification of Isolated Yeast from Vulvovaginal Candidiasis.Iranian journal of basic medical sciences · 2011Article
- PCR melting profile (PCR MP)--a new tool for differentiation of Candida albicans strains.BMC infectious diseases · 2009Article
- Article
- Immunopathogenesis of oropharyngeal candidiasis in human immunodeficiency virus infection.Clinical microbiology reviews · 2004Review
- Genotyping and antifungal susceptibility profile of Dipodascus capitatus isolates causing disseminated infection in seven hematological patients of a tertiary hospital.Journal of clinical microbiology · 2004Article
- Antifungal activities of two new azasordarins, GW471552 and GW471558, in experimental models of oral and vulvovaginal candidiasis in immunosuppressed rats.Antimicrobial agents and chemotherapy · 2001Article
- PCR fingerprinting of Candida albicans associated with chronic hyperplastic candidosis and other oral conditions.Journal of clinical microbiology · 2001Article
- Antifungal efficacy of GM237354, a sordarin derivative, in experimental oral candidiasis in immunosuppressed rats.Antimicrobial agents and chemotherapy · 2001Article
- The ins and outs of DNA fingerprinting the infectious fungi.Clinical microbiology reviews · 2000Review
- Clonal and spontaneous origins of fluconazole resistance in Candida albicans.Journal of clinical microbiology · 2000Article
- Species and genotypic diversities and similarities of pathogenic yeasts colonizing women.Journal of clinical microbiology · 1999Article
- The evolutionary biology and population genetics underlying fungal strain typing.Clinical microbiology reviews · 1999Review
- Molecular tracking of Candida albicans in a neonatal intensive care unit: long-term colonizations versus catheter-related infections.Journal of clinical microbiology · 1997Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Candida albicans strain delineation by karyotyping. NotI restriction pattern analysis, hybridization with specific probe 27A, and PCR fingerprinting with the phage M13 core sequence were performed with 30 isolates from the oral cavities of 30 human immunodeficiency virus (HIV)-infected patients and 8 reference strains. Within the panel of clinical isolates, 20 were geographically related, although 10 isolates were susceptible to fluconazole and 10 isolates were resistant to fluconazole. The remaining isolates used in this study were fluconazole resistant and geographically unrelated. A composite DNA type was defined for each of the strains as the combination of types obtained by the four molecular methods. By this procedure, a great diversity of DNA types was found among isolates from the oropharynges of HIV-infected individuals with oral candidiasis. This diversity was not reduced when isolates were evaluated on the basis of whether they came from the same geographical locale and whether they were fluconazole resistant. These data refute the idea of a clonal origin for fluconazole-resistant strains among HIV-positive patients. Karyotyping was the least discriminatory method, yielding 19 DNA types among the 38 strains analyzed. Conversely, hybridization with the 27A probe showed a unique DNA pattern for each of the strains examined in this study. Our results demonstrate that at least two different molecular methods are needed for Candida albicans typing and that there is a great deal of strain variation within the species, irrespective of place of origin or antifungal resistance patterns.
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