ArticleImmunology1997
Nitric oxide increased interleukin-4 expression in T lymphocytes.
Article in Immunology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 90 citations in OpenAlex.
- Opportunities for Nitric Oxide in Potentiating Cancer Immunotherapy.Pharmacological reviews · 2022Review
- Anti-inflammatory cytokines in endometriosis.Cellular and molecular life sciences : CMLS · 2019Review
- Article
- Targeting the overproduction of peroxynitrite for the prevention and reversal of paclitaxel-induced neuropathic pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Nitric oxide produces HLA-G nitration and induces metalloprotease-dependent shedding creating a tolerogenic milieu.Immunology · 2009Article
- Elevated asymmetric dimethylarginine alters lung function and induces collagen deposition in mice.American journal of respiratory cell and molecular biology · 2009Article
- Regulation of apoptosis-related genes by nitric oxide in cancer.Nitric oxide : biology and chemistry · 2008Review
- Regulatory cells and immunosuppressive cytokines: parasite-derived factors induce immune polarization.Journal of biomedicine & biotechnology · 2007Article
- Immunoregulatory and antimicrobial effects of nitrogen oxides.Proceedings of the American Thoracic Society · 2006Review
- Does nitric oxide play a role in maternal tolerance towards the foetus?Journal of physiology and biochemistry · 2004Review
- Multiple roles of nitric oxide in the airways.Thorax · 2003Review
- Comparative study on the immunogenicity between recombinant MS-Sj26GST vaccine and recombinant BCG-Sj26GST vaccine in Schistosoma japonicum.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2003Article
- Nitric oxide-enhanced resistance to oral candidiasis.Immunology · 2001Article
- Apocynin and 1400 W prevents airway hyperresponsiveness during allergic reactions in mice.British journal of pharmacology · 2001Article
- Comparative study on the immunogenicity between Hsp70 DNA vaccine and Hsp65 DNA vaccine in human Mycobacterium tuberculosis.Journal of Tongji Medical University = Tong ji yi ke da xue xue bao · 2001Article
- Cellular and cytokine correlates of mucosal protection in murine model of oral candidiasis.Infection and immunity · 2000Article
- Modulation of autoimmune diseases by nitric oxide.Immunologic research · 2000Review
- Effects of intrinsic nitric oxide on the expression of interleukin-4 and IFN-gamma mRNA in the bronchial and lung tissues of sensitized rats.Journal of Tongji Medical University = Tong ji yi ke da xue xue bao · 2000Article
- Zinc finger transcription factors as molecular targets for nitric oxide-mediated immunosuppression: inhibition of IL-2 gene expression in murine lymphocytes.Molecular medicine (Cambridge, Mass.) · 1999Article
- Inducible nitric oxide synthase-deficient mice develop enhanced type 1 cytokine-associated cellular and humoral immune responses after vaccination with attenuated Schistosoma mansoni cercariae but display partially reduced resistance.Infection and immunity · 1998Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) is a regulator of many biological functions including T helper 1 (Th1)/T helper 2 cells balance. It has been demonstrated that NO inhibits the secretion of interleukin-2 (IL-2) and interferon-gamma on Th1 cells. Here we showed that, in addition to the suppression of IL-2 production, NO-generating agents sodium nitroprusside (SNP) and S-nitroso-N-acetylpenicillamine (SNAP) increased the secretion of IL-4 both in Th2 clones and EL4 T cells. The additive effect was dependent on the dose of SNP and SNAP. Augmentation of IL-4 production was detected with 1 microM SNP, and up to threefold increase in IL-4 secretion could be observed with higher concentrations of SNP/SNAP. NO also weakly increased the activation of IL-4 promoter. In contrast, NO markedly inhibited the induction of IL-2 promoter, which could account for most of the reduction in IL-2 production. Analysis of the transcriptional elements on IL-2 and IL-4 promoters revealed a selective inactivation of NF-kappa B and NF-AT. It is suggested that despite the complex feedback network regulating NO production, the enhanced IL-4 expression would lead to the expansion of Th2 cells once NO is generated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.