Trial reportGut1997
Efficacy of primed infusions with high dose ranitidine and omeprazole to maintain high intragastric pH in patients with peptic ulcer bleeding: a prospective randomised controlled study.
Trial report in Gut, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 130 citations in OpenAlex.
- Systematic review and meta-analysis of proton pump inhibitor therapy in peptic ulcer bleeding.BMJ (Clinical research ed.) · 2005Pooled it
- Repeated Famotidine Administration Results in a Diminished Effect on Intragastric pH in Dogs.Journal of veterinary internal medicine · 2017Trial
- Intravenous pantoprazole versus ranitidine for prevention of rebleeding after endoscopic hemostasis of bleeding peptic ulcers.World journal of gastroenterology · 2004Trial
- Skipping the Drip: Intravenous Proton Pump Inhibitor Bolus Therapy Leads to Poor Outcomes in High-Risk Bleeding.Cureus · 2020Article
- ACVIM consensus statement: Support for rational administration of gastrointestinal protectants to dogs and cats.Journal of veterinary internal medicine · 2018Article
- Proton Pump Inhibitor Therapy before and after Endoscopic Submucosal Dissection: A Review.Diagnostic and therapeutic endoscopy · 2012Article
- Intravenous proton pump inhibitors for peptic ulcer bleeding: Clinical benefits and limits.World journal of gastrointestinal endoscopy · 2011Article
- How evidence-based are current guidelines for managing patients with peptic ulcer bleeding?World journal of gastrointestinal surgery · 2010Article
- Gastric acid inhibition in the treatment of peptic ulcer hemorrhage.Current gastroenterology reports · 2009Review
- Ulcers: adjuvant PPIs to prevent major ulcer bleeds.Nature reviews. Gastroenterology & hepatology · 2009Article
- Management of upper gastrointestinal bleeding.Current gastroenterology reports · 2008Review
- Review
- Pharmacologic treatment of peptic ulcer bleeding.Current treatment options in gastroenterology · 2007Article
- Some Observations on PPI Therapy for Bleeding Ulcer.Gastroenterology & hepatology · 2006Article
- Appropriate use of intravenous proton pump inhibitors in the management of bleeding peptic ulcer.Digestive diseases and sciences · 2005Review
- Switching between intravenous and oral pantoprazole.Journal of clinical gastroenterology · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn healthy subjects, continuous infusions of high dose ranitidine and omeprazole produce high intragastric pH values.
aimTo test the hypothesis that both drugs also maintain high intragastric pH values in patients with bleeding ulcers. PATIENTS AND
methodsIn two parallel studies, 20 patients with bleeding duodenal ulcers and 20 patients with bleeding gastric ulcers were randomly assigned to receive either ranitidine (0.25 mg/kg/hour after a bolus of 50 mg) or omeprazole (8 mg/hour after a bolus of 80 mg) for 24 hours. Intragastric pH was continuously recorded with a glass electrode placed 5 cm below the cardia.
resultsBoth drugs rapidly raised the intragastric pH above 6. During the second 12 hour period, however, the percentage of time spent below a pH of 6 was 0.15% with omeprazole and 20.1% with ranitidine (p = 0.0015) in patients with duodenal ulcer; in patients with gastric ulcer it was 0.1% with omeprazole and 46.1% with ranitidine (p = 0.002).
conclusionsPrimed infusions of omeprazole after a bolus produced consistently high intragastric pH values in patients with bleeding peptic ulcers, whereas primed infusions with ranitidine were less effective during the second half of a 24 hour treatment course. This loss of effectiveness may be due to tolerance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.