ArticleBritish journal of cancer1997
Frequent reduction or loss of DCC gene expression in human osteosarcoma.
Article in British journal of cancer, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 29 citations in OpenAlex.
- The genetics of osteosarcoma.Sarcoma · 2012Article
- Osteosarcoma development and stem cell differentiation.Clinical orthopaedics and related research · 2008Review
- Inheritance of osteosarcoma and Paget's disease of bone: a familial loss of heterozygosity study.The Journal of molecular diagnostics : JMD · 2001Article
- Human colon cancer cells deficient in DCC produce abnormal transcripts in progression of carcinogenesis.Digestive diseases and sciences · 2001Article
- beta- Catenin mutations and aberrant nuclear expression during endometrial tumorigenesis.British journal of cancer · 2001Article
- Loss of DCC gene expression during ovarian tumorigenesis: relation to tumour differentiation and progression.British journal of cancer · 2000Article
- DNA copy number losses in human neoplasms.The American journal of pathology · 1999Review
- CDKN2A gene deletions and loss of p16 expression occur in osteosarcomas that lack RB alterations.The American journal of pathology · 1998Article
- Up-regulation of CD44 variant exon expression in endometrial carcinomas: analysis of mRNA and protein isoforms, and relation to clinicopathological factors.Japanese journal of cancer research : Gann · 1998Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 'deleted in colon carcinoma' (DCC) gene has been considered a candidate tumour-suppressor gene that encodes for a transmembrane protein with strong structural similarity to members of the superfamily of neural cell adhesion molecules. It has been mapped to the chromosomal region 18q21.1 and it is implicated in cellular differentiation and developmental processes. In human osteosarcoma allelic loss frequently occurs on the long arm of chromosome 18, suggesting a possible involvement of the DCC gene in the pathogenesis of this tumour entity. In the present study the mRNA and protein expression and rearrangements at the DNA level of the DCC gene were addressed in 25 osteosarcomas and several tumour cell lines, including osteosarcoma- and colon carcinoma-derived cell lines. Using an reverse transcriptase polymerase chain reach in (RT-PCR)-based approach DCC expression was found to be lost or substantially reduced in 14 of 19 high-grade osteosarcomas, in three of six lower grade osteosarcomas and most of the tumour cell lines, in contrast to normally differentiated osteoblasts. Immunohistochemical studies on DCC protein expression of 14 selected tumours correlated well with the RT-PCR-based results. In view of the putative tumour-suppressor characteristics of the DCC gene its loss or reduction of expression could be a specific event in the development or progression of many high-grade osteosarcomas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.