ArticleThe EMBO journal1997
A model for extradenticle function as a switch that changes HOX proteins from repressors to activators.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 145 citations in OpenAlex.
- PBX-dependent and independent Hox programs establish and maintain motor neuron terminal Identity.bioRxiv : the preprint server for biology · 2025Article
- Mapping Gene Expression in Whole Larval Brains ofMethods and protocols · 2025Article
- Stability and dynamics of extradenticle modulates its function.Current research in structural biology · 2024Article
- Massively parallel reporter perturbation assays uncover temporal regulatory architecture during neural differentiation.Nature communications · 2022Article
- The Hox protein conundrum: The "specifics" of DNA binding for Hox proteins and their partners.Developmental biology · 2021Review
- The Hox transcription factor Ubx stabilizes lineage commitment by suppressing cellular plasticity ineLife · 2019Article
- HOX transcription factors are potential targets and markers in malignant mesothelioma.BMC cancer · 2016Article
- Developmental Patterning as a Quantitative Trait: Genetic Modulation of the Hoxb6 Mutant Skeletal Phenotype.PloS one · 2016Article
- Roles of cofactors and chromatin accessibility in Hox protein target specificity.Epigenetics & chromatin · 2016Article
- Role of Homothorax in region specific regulation of Deformed in embryonic neuroblasts.Mechanisms of development · 2015Article
- Dangerous liaisons: cooperation between Pbx3, Meis1 and Hoxa9 in leukemia.Haematologica · 2015Article
- Insights into the Transcriptional Architecture of Behavioral Plasticity in the Honey Bee Apis mellifera.Scientific reports · 2015Article
- Hox regulation of transcription: more complex(es).Developmental dynamics : an official publication of the American Association of Anatomists · 2014Review
- Pbx homeodomain proteins: TALEnted regulators of limb patterning and outgrowth.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Review
- Genome-wide analysis of the binding of the Hox protein Ultrabithorax and the Hox cofactor Homothorax in Drosophila.PloS one · 2011Article
- Article
- Transient activation of meox1 is an early component of the gene regulatory network downstream of hoxa2.Molecular and cellular biology · 2011Article
- Dissecting the functional specificities of two Hox proteins.Genes & development · 2010Article
- Segment-specific neuronal subtype specification by the integration of anteroposterior and temporal cues.PLoS biology · 2010Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The Drosophila EXD protein and its mammalian counterparts, the PBX proteins, have been proposed to function in HOX target selectivity. Here we show that exd function is required for the autoactivation phase of Dfd expression in the posterior head. Mutations that change the affinity of a small autoactivation element for EXD protein result in corresponding changes in the element's embryonic activity. Our data suggest that the EXD and DFD proteins directly activate this element in maxillary cells without cooperatively binding to a specialized heterodimer binding site. Based on the types of homeotic transformations and changes in gene expression observed in exd mutant embryos, we propose a new model for EXD/PBX action in which these proteins are required for HOX protein transcriptional activation functions, but dispensable for HOX transcriptional repression functions. Although the selection of a specific target gene by a HOX protein versus another may be explained in some cases by the selective modulation of HOX binding specificity by EXD, we favor the idea that EXD interacts in a more general sense with most HOX proteins to switch them into a state where they are capable of transcriptional activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.