ArticleMolecular and cellular biology1997
The absence of the transcription activator TFE3 impairs activation of B cells in vivo.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Endolysosomal vesicles at the center of B cell activation.The Journal of cell biology · 2024Review
- MiT Family Transcriptional Factors in Immune Cell Functions.Molecules and cells · 2021Review
- TFEB and TFE3: The art of multi-tasking under stress conditions.Transcription · 2017Article
- TFEB and TFE3: Linking Lysosomes to Cellular Adaptation to Stress.Annual review of cell and developmental biology · 2016Review
- TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages.Autophagy · 2016Article
- Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers.Nature reviews. Urology · 2014Review
- Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis.Cellular and molecular life sciences : CMLS · 2014Review
- The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris.Science signaling · 2014Article
- Embryonic expression of zebrafish MiT family genes tfe3b, tfeb, and tfec.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- Regulation of the MiTF/TFE bHLH-LZ transcription factors through restricted spatial expression and alternative splicing of functional domains.Nucleic acids research · 2004Article
- Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- A new class of errant DNA polymerases provides candidates for somatic hypermutation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2001Review
- JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome.The Journal of clinical investigation · 2000Article
- Article
- Transcriptional activation by ETS and leucine zipper-containing basic helix-loop-helix proteins.Molecular and cellular biology · 1999Article
- Age-resolving osteopetrosis: a rat model implicating microphthalmia and the related transcription factor TFE3.The Journal of experimental medicine · 1998Article
- ETS-core binding factor: a common composite motif in antigen receptor gene enhancers.Molecular and cellular biology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
TFE3 is a ubiquitously expressed member of the TFE3/mi family of basic helix loop helix zipper transcription factors. TFE3 binds to muE3 sites located in the immunoglobulin heavy-chain (IgH) intronic enhancer, heavy-chain variable region promoters, the Ig kappa intronic enhancer, and regulatory sites in other genes. To understand the role of TFE3 in Ig expression and lymphoid development, we used embryonic stem (ES) cell-mediated gene targeting and RAG2-/- blastocyst complementation to generate mice which lack TFE3 in their B and T lymphocytes. TFE3- ES cells fully reconstitute the B- and T-cell compartments, giving rise to normal patterns of IgM+ B220+ B cells and CD4+ and CD8+ T cells. However, TFE3- B cells show several defects consistent with poor B-cell activation. Serum IgM levels are reduced twofold and IgG and IgA isotypes are reduced three- to sixfold in the TFE3- chimeras even though in vitro, the TFE3- splenocytes secrete normal levels of all isotypes in response to lipopolysaccharide activation. Peripheral TFE3- B cells also show reduced surface expression of CD23 and CD24 (heat-stable antigen).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.