ArticleMolecular and cellular biology1997
Accurate positioning of RNA polymerase II on a natural TATA-less promoter is independent of TATA-binding-protein-associated factors and initiator-binding proteins.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 98 citations in OpenAlex.
- Zinc knuckle of TAF1 is a DNA binding module critical for TFIID promoter occupancy.Scientific reports · 2018Article
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- High constitutive activity of a broad panel of housekeeping and tissue-specificGenes & development · 2017Article
- Polycomblike protein PHF1b: a transcriptional sensor for GABA receptor activity.BMC pharmacology & toxicology · 2013Article
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- Yin Yang 1 contains G-quadruplex structures in its promoter and 5'-UTR and its expression is modulated by G4 resolvase 1.Nucleic acids research · 2012Article
- Phospholipase D2 (PLD2) shortens the time required for myeloid leukemic cell differentiation: mechanism of action.The Journal of biological chemistry · 2012Article
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- Regulation of the human ascorbate transporter SVCT2 exon 1b gene by zinc-finger transcription factors.Free radical biology & medicine · 2011Article
- Characterization of sINR, a strict version of the Initiator core promoter element.Nucleic acids research · 2009Article
- Two new chromodomain-containing proteins that associate with heterochromatin in Sciara coprophila chromosomes.Chromosoma · 2009Article
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- Bile acids repress E-cadherin through the induction of Snail and increase cancer invasiveness in human hepatobiliary carcinoma.Cancer science · 2008Article
- Transcriptional co-expression and co-regulation of genes coding for components of the oxidative phosphorylation system.BMC genomics · 2008Article
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- Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE.Nucleic acids research · 2005Article
- Core promoter structure in the oomycete Phytophthora infestans.Eukaryotic cell · 2004Article
- An important role for RUNX3 in human L1 transcription and retrotransposition.Nucleic acids research · 2003Article
- JFC1 is transcriptionally activated by nuclear factor-kappaB and up-regulated by tumour necrosis factor alpha in prostate carcinoma cells.The Biochemical journal · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Two promoter elements, the TATA element and initiator (Inr), are capable of directing specific transcription initiation of protein-encoding genes by RNA polymerase II (RNAPII). Although binding to the TATA element by the TATA-binding protein (TBP) has been shown to be the initial recognition step in transcription complex formation in vitro, the mechanism through which the basal machinery assembles into a functional complex on TATA-less promoters is controversial. Evidence supporting numerous models of Inr-mediated transcription complex formation exists, including the nucleation of a complex by Inr-binding proteins, a component of the TFIID complex, or a specific upstream activator common to many TATA-less promoters, Sp1. Using various techniques, we have undertaken a systematic analysis of the natural TATA-less human DNA polymerase beta (beta-pol) gene promoter. Although the beta-pol promoter contains upstream Sp1 elements and a functional Inr that binds YY1, neither of these factors is essential for Inr-mediated transcription complex formation. A complex containing TBP, TFIIB, TFIIF, and RNAPII (DBPolF complex) is capable of forming on the promoter in an Inr-dependent manner. A single point mutation within the Inr that affects DBPolF complex formation diminishes beta-pol transcriptional activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.