ArticleNucleic acids research1997
CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues.
Article in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 128 citations in OpenAlex.
- Article
- Transcription factor competition at the γ-globin promoters controls hemoglobin switching.Nature genetics · 2021Article
- NF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region.Nature communications · 2019Article
- Article
- The Hap Complex in Yeasts: Structure, Assembly Mode, and Gene Regulation.Frontiers in microbiology · 2019Review
- The animal nuclear factor Y: an enigmatic and important heterotrimeric transcription factor.American journal of cancer research · 2018Review
- The OsHAPL1-DTH8-Hd1 complex functions as the transcription regulator to repress heading date in rice.Journal of experimental botany · 2017Article
- Molecular characterization of hap complex components responsible for methanol-inducible gene expression in the methylotrophic yeast Candida boidinii.Eukaryotic cell · 2015Article
- MADS domain transcription factors mediate short-range DNA looping that is essential for target gene expression in Arabidopsis.The Plant cell · 2013Article
- ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability.Oncogene · 2011Article
- Neuronal expression of TATA box-binding protein containing expanded polyglutamine in knock-in mice reduces chaperone protein response by impairing the function of nuclear factor-Y transcription factor.Brain : a journal of neurology · 2011Article
- Transcriptional regulation of the human neutral ceramidase gene.Archives of biochemistry and biophysics · 2011Article
- AP-1 binding transcriptionally regulates human neutral ceramidase.Archives of biochemistry and biophysics · 2011Article
- NF-YC functions as a corepressor of agonist-bound mineralocorticoid receptor.The Journal of biological chemistry · 2010Article
- bZIP28 and NF-Y transcription factors are activated by ER stress and assemble into a transcriptional complex to regulate stress response genes in Arabidopsis.The Plant cell · 2010Article
- Regulation of the p53 transcriptional response by structurally diverse core promoters.Genes & development · 2010Article
- NF-YC complexity is generated by dual promoters and alternative splicing.The Journal of biological chemistry · 2009Article
- Nuclear factor Y is required for basal activation and chromatin accessibility of fibroblast growth factor receptor 2 promoter in osteoblast-like cells.The Journal of biological chemistry · 2009Article
- Regulation of mouse Scgb3a1 gene expression by NF-Y and association of CpG methylation with its tissue-specific expression.BMC molecular biology · 2008Article
- Genome-wide identification and expression analysis of the NF-Y family of transcription factors in Triticum aestivum.Plant molecular biology · 2007Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Both the TATA and CCAAT boxes are widespread promoter elements and their binding proteins, TBP and NF-Y, are extremely conserved in evolution. NF-Y is composed of three subunits, NF-YA, NF-YB and NF-YC, all necessary for DNA binding. NF-YB and NF-YC contain a putative histone-like motif, a domain also present in TBP-associated factors (TAFIIs) and in the subunits of the transcriptional repressor NC2. Immunopurification of holo-TFIID with anti-TBP and anti-TAFII100 antibodies indicates that a fraction of NF-YB associates with TFIID in the absence of NF-YA. Sedimentation velocity centrifugation experiments confirm that two pools of NF-YB, and most likely NF-YC, exist: one associated with NF-YA and binding to the CCAAT box; another involved in high molecular weight complexes. We started to dissect NF-Y-TFIID interactions by showing that: (i) NF-YB and NF-YC interact with TBP in solution, both separately and once bound to each other; (ii) short stretches of both NF-YB and NF-YC located within the evolutionary conserved domains, adjacent to the putative histone fold motifs, are necessary for TBP binding; (iii) TBP single amino acid mutants in the HS2 helix, previously shown to be defective in NC2 binding, are also unable to bind NF-YB and NF-YC.
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Registered trials
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