ArticleNucleic acids research1997
Isolation and characterization of the Schizosaccharomyces pombe rhp9 gene: a gene required for the DNA damage checkpoint but not the replication checkpoint.
Article in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 100 citations in OpenAlex.
- Critical Function of γH2A in S-Phase.PLoS genetics · 2015Article
- Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4(TopBP1).Molecular cell · 2013Article
- Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1.PLoS genetics · 2013Article
- Regulatory networks integrating cell cycle control with DNA damage checkpoints and double-strand break repair.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- BRCT domains: easy as one, two, three.Cell cycle (Georgetown, Tex.) · 2011Review
- Redundant mechanisms prevent mitotic entry following replication arrest in the absence of Cdc25 hyper-phosphorylation in fission yeast.PloS one · 2011Article
- TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint.The EMBO journal · 2010Article
- BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint.Molecular and cellular biology · 2010Article
- Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair.Genes & development · 2008Article
- Article
- Effects of BRCA1 transgene expression on murine mammary gland development and mutagen-induced mammary neoplasia.International journal of biological sciences · 2007Article
- Mrc1 and Srs2 are major actors in the regulation of spontaneous crossover.The EMBO journal · 2006Article
- Production of reactive oxygen species in response to replication stress and inappropriate mitosis in fission yeast.Journal of cell science · 2006Article
- Cooperative control of Crb2 by ATM family and Cdc2 kinases is essential for the DNA damage checkpoint in fission yeast.Molecular and cellular biology · 2005Article
- The fission yeast Crb2/Chk1 pathway coordinates the DNA damage and spindle checkpoint in response to replication stress induced by topoisomerase I inhibitor.Molecular and cellular biology · 2005Article
- Germinating fission yeast spores delay in G1 in response to UV irradiation.BMC cell biology · 2004Article
- Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast.Molecular and cellular biology · 2004Article
- Regulation of checkpoint kinases through dynamic interaction with Crb2.The EMBO journal · 2004Article
- Two-hybrid search for proteins that interact with Sad1 and Kms1, two membrane-bound components of the spindle pole body in fission yeast.Molecular genetics and genomics : MGG · 2004Article
- Retention but not recruitment of Crb2 at double-strand breaks requires Rad1 and Rad3 complexes.Molecular and cellular biology · 2003Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Checkpoint controls exist in eukaryotic cells to ensure that cells do not enter mitosis in the presence of DNA damage or unreplicated chromosomes. In Schizosaccharomyces pombe many of the checkpoint genes analysed to date are required for both the DNA damage and the replication checkpoints, an exception being chk1 . We report here on the characterization of nine new methylmethane sulphonate (MMS)-sensitive S.pombe mutants, one of which is defective in the DNA damage checkpoint but not the replication checkpoint. We have cloned and sequenced the corresponding gene. The predicted protein is most similar to the Saccharomyces cerevisiae Rad9 protein, having 46% similarity and 26% identity. The S.pombe protein, which we have named Rhp9 (Rad9 homologue in S. pombe) on the basis of structural and phenotypic similarity, also contains motifs present in BRCA1 and 53BP1. Deletion of the gene is not lethal and results in a DNA damage checkpoint defect. Epistasis analysis with other S.pombe checkpoint mutants indicates that rhp9 acts in a process involving the checkpoint rad genes and that the rhp9 mutant is phenotypically very similar to chk1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.