ArticleThe Journal of clinical investigation1997
Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 147 citations in OpenAlex.
- Diagnostic value of combined islet antigen-reactive T cells and autoantibodies assays for type 1 diabetes mellitus.Journal of diabetes investigation · 2021Article
- Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?).Nature reviews. Endocrinology · 2021Review
- Application of IgG-derived natural Treg epitopes (IgG Tregitopes) to antigen-specific tolerance induction in a murine model of type 1 diabetes.Journal of diabetes research · 2013Article
- Antigen-specific therapeutic approaches in Type 1 diabetes.Cold Spring Harbor perspectives in medicine · 2012Review
- Molecular mimicry as a mechanism of autoimmune disease.Clinical reviews in allergy & immunology · 2012Review
- T cell recognition of autoantigens in human type 1 diabetes: clinical perspectives.Clinical & developmental immunology · 2011Review
- Characterization of CD4+ T cells specific for glutamic acid decarboxylase (GAD65) and proinsulin in a patient with stiff-person syndrome but without type 1 diabetes.Diabetes/metabolism research and reviews · 2010Article
- Article
- Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes.Clinical and experimental immunology · 2007Review
- Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Animal models have little to teach us about type 1 diabetes: 1. In support of this proposal.Diabetologia · 2004Review
- T cells recognize multiple GAD65 and proinsulin epitopes in human type 1 diabetes, suggesting determinant spreading.Journal of clinical immunology · 2004Article
- T-cell epitopes in type 1 diabetes.Current diabetes reports · 2004Review
- Autoimmune diabetes: ongoing development of immunological intervention strategies targeted directly against autoreactive T cells.The review of diabetic studies : RDS · 2004Article
- Modulation of antigen presentation by autoreactive B cell clones specific for GAD65 from a type I diabetic patient.Clinical and experimental immunology · 2004Article
- Improved in planta expression of the human islet autoantigen glutamic acid decarboxylase (GAD65).Transgenic research · 2003Article
- Vaccine therapies for the prevention of type 1 diabetes mellitus.Paediatric drugs · 2003Review
- Review
- DR, DQ, and you: MHC alleles and autoimmunity.The Journal of clinical investigation · 2001Review
- Intradermal skin test with diabetes specific antigens in patients with type 1 diabetes.Clinical and experimental immunology · 2001Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutamic acid decarboxylase (GAD) has been defined as a major target antigen in insulin-dependent diabetes mellitus (IDDM). To identify the molecular ligands triggering a T cell response to GAD, a panel of human GAD65-specific T lymphocyte lines was generated from peripheral blood of three recent onset IDDM patients. All lines derived from a patient expressing the high-risk-conferring HLA-DR*0301/ *0401 haplotypes recognized a single epitope localized between amino acid positions 270 and 283 of GAD65, a stretch that is located in close proximity to the homology region shared with Coxsackie virus P2-C protein. All lines with this specificity were restricted to the DRA, B1*0401 product of the DR4 haplotype. Analysis of the GAD-specific T cell response in a second patient homozygous for DR4 haplotypes demonstrated that the same DRA, B1*0401 allele selected T cells specific for a different determinant. The T cell response profile in a third patient showed that DR*1501/ *1601-encoding haplotypes could present at least three different epitopes to GAD65-specific T lymphocytes. One of these epitopes was presented by a DR allele associated with the resistance-conferring DRB1*1501 haplotype. GAD-specific T cell lines could not be isolated from HLA class II-matched normal individuals. Our data reveal that (a) the T cell response to GAD65 is quite heterogenous in recent onset IDDM patients; (b) HLA-DR, not DQ, seems to be the principal restriction element used by T cells present at the onset of the disease; and (c) T cells responding to epitopes containing identical sequences to Coxsackie virus P2-C protein were not detected.
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