Evidence map›Paper›PMID 9151879›Full record

ArticleJournal of virology1997

Gene transfer to human cells using retrovirus vectors produced by a new polytropic packaging cell line.

S A Loiler, N L DiFronzo, C A Holland

Abstract read
In one paragraph

Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. A conserved mechanism of retrovirus restriction in mammals.Proceedings of the National Academy of Sciences of the United States of America · 2000
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

S A LoilerGraduate Program in Immunology and Virology, University of Massachusetts Medical Center, Worcester 01655, USA.
N L DiFronzo
C A Holland

Funding

ONCOGENICITY OF MINK CELL FOCUS-INDUCING RETROVIRUSESR01CA041510 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HOLLAND, CHRISTIE A. · 1986 to 1994
–
NCI NIH HHS CA-41510
6 · The paper itself

Abstract

We report here the construction of a new packaging cell line, called MPAC, that packages defective retroviral vectors in viral particles with envelope proteins derived from a Moloney mink cell focus-inducing (MCF) polytropic virus. We characterized the tropism of MPAC-packaged retroviral vectors and show that some human cell lines can be infected with these vectors while others cannot. In addition, we show that some human cells fully support MCF virus replication while others either partially or fully restrict MCF virus replication.

Indexed as

Cell LineGenetic VectorsGene Transfer Techniques3T3 CellsAnimalsCHO CellsCricetinaeDefective VirusesHumansHybrid CellsMiceMink Cell Focus-Inducing VirusesMuridaeRetroviridaeSpecies SpecificityViral Interference

Identifiers

PMID9151879
PMCPMC191707

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.