ArticleThe Journal of clinical investigation1997
Endogenous endothelins mediate increased distal tubule acidification induced by dietary acid in rats.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 75 citations in OpenAlex.
- Metabolic Acidosis in Patients with Chronic Kidney Disease: Diagnosis, Pathogenesis, and Treatment-A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Article
- Pathophysiology of Diet-Induced Acid Stress.International journal of molecular sciences · 2024Review
- Hidden Acid Retention with Normal Serum Bicarbonate Level in Chronic Kidney Disease.Electrolyte & blood pressure : E & BP · 2023Review
- Mechanisms of Metabolic Acidosis-Induced Kidney Injury in Chronic Kidney Disease.Journal of the American Society of Nephrology : JASN · 2020Article
- Acid Base Balance and Progression of Kidney Disease.Seminars in nephrology · 2019Review
- Chronic lithium treatment induces novel patterns of pendrin localization and expression.American journal of physiology. Renal physiology · 2018Article
- Kidney Response to the Spectrum of Diet-Induced Acid Stress.Nutrients · 2018Article
- Effects of dietary interventions on incidence and progression of CKD.Nature reviews. Nephrology · 2014Review
- Metabolic acidosis and the progression of chronic kidney disease.BMC nephrology · 2014Article
- Dietary acid load: a novel nutritional target in chronic kidney disease?Advances in chronic kidney disease · 2013Review
- Physiology of endothelin and the kidney.Comprehensive Physiology · 2011Review
- Increased endothelin activity mediates augmented distal nephron acidification induced by dietary protein.Transactions of the American Clinical and Climatological Association · 2005Article
- NHE2-mediated bicarbonate reabsorption in the distal tubule of NHE3 null mice.The Journal of physiology · 2004Article
- Endothelin-1/endothelin-B receptor-mediated increases in NHE3 activity in chronic metabolic acidosis.The Journal of clinical investigation · 2001Article
- Reduced extracellular pH increases endothelin-1 secretion by human renal microvascular endothelial cells.The Journal of clinical investigation · 1998Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
We examined if endogenous endothelins mediate the decreased HCO3 secretion and increased H+ secretion in in vivo-perfused distal tubules of rats fed dietary acid as (NH4)2SO4. Animals given (NH4)2SO4 drinking solution had higher endothelin-1 addition to renal interstitial fluid than those given distilled H2O (480+/-51 vs. 293+/-32 fmol g kidney wt(-1) min(-1), respectively, P < 0.03). (NH4)2SO4-ingesting animals infused with bosentan (10 mg/kg) to inhibit A- and B-type endothelin receptors had higher HCO3 secretion than baseline (NH4)2SO4 animals (-4.7+/-0.4 vs. -2.4+/-0.3 pmol mm(-1) min(-1), P < 0.01), but (NH4)2SO4 animals given a specific inhibitor of A-type endothelin receptors (BQ-123) did not (-2.0+/-0.2 pmol mm(-1) min(-1), P = NS vs. baseline). H+ secretion was lower in bosentan-infused compared with baseline (NH4)2SO4 animals (27.7+/-2.5 vs. 43.9+/-4.0 pmol mm(-1) min(-1), P < 0.03), but that for BQ-123-infused (NH4)2SO4 animals was not (42.9+/-4.2 pmol mm(-1) min(-1), P = NS vs. baseline). Bosentan had no effect on distal tubule HCO3 or H+ secretion in control animals. The data show that dietary acid increases endothelin-1 addition to renal interstitial fluid and that inhibition of B- but not A-type endothelin receptors blunts the decreased HCO3 secretion and increased H+ secretion in the distal tubule of animals given dietary acid. The data are consistent with endogenous endothelins as mediators of increased distal tubule acidification induced by dietary acid.
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