ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
The low-affinity neurotrophin receptor p75 regulates the function but not the selective survival of specific subpopulations of sensory neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 79 citations in OpenAlex.
- Metabolic Control of Sensory Neuron Survival by the p75 Neurotrophin Receptor in Schwann Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Automated analyses for single-fiber electrophysiological recordings using a newly developed Microsoft Excel application and graphical user interface.Journal of neuroscience methods · 2021Article
- Article
- Depiction of Oral Tumor-Induced Trigeminal Afferent Responses Using Single-Fiber Electrophysiology.Scientific reports · 2019Article
- The neurotrophin receptor p75 regulates gustatory axon branching and promotes innervation of the tongue during development.Neural development · 2014Article
- TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Peripheral somatosensation: a touch of genetics.Current opinion in genetics & development · 2011Review
- Mice lacking the p75 receptor fail to acquire a normal complement of taste buds and geniculate ganglion neurons by adulthood.The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology · 2006Article
- Neurotrophin-regulated signalling pathways.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2006Review
- The role of the p75 neurotrophin receptor in the morphology of dorsal root ganglion cells in streptozotocin diabetic mice: effects of sciatic nerve crush.Diabetologia · 2004Article
- PKA phosphorylates the p75 receptor and regulates its localization to lipid rafts.The EMBO journal · 2003Article
- Knockout of p75NTR does not alter the viability of striatal neurons following a metabolic or excitotoxic injury.Journal of molecular neuroscience : MN · 2003Article
- Neurotrophins: roles in neuronal development and function.Annual review of neuroscience · 2001Review
- Induction of postnatal schwann cell death by the low-affinity neurotrophin receptor in vitro and after axotomy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Ceramide signaling downstream of the p75 neurotrophin receptor mediates the effects of nerve growth factor on outgrowth of cultured hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Overexpression of nerve growth factor in skin selectively affects the survival and functional properties of nociceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- POU domain factor Brn-3a controls the differentiation and survival of trigeminal neurons by regulating Trk receptor expression.Development (Cambridge, England) · 1999Article
- Expression of Trk receptors in the developing mouse trigeminal ganglion: in vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkC.Development (Cambridge, England) · 1999Article
- Absence of the p75 neurotrophin receptor alters the pattern of sympathosensory sprouting in the trigeminal ganglia of mice overexpressing nerve growth factor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Neurotrophin 4 is required for the survival of a subclass of hair follicle receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mice with a targeted deletion of the low-affinity neurotrophin receptor p75 (p75-/-) exhibit a 50% loss of large- and small-diameter sensory neurons in the dorsal root ganglion. Using neurophysiological recording techniques, we now show that p75 is not required for the survival of specific, functionally defined subpopulations of sensory neurons. Rather, p75-/- mice exhibit losses of neurons that subserve nociceptive as well as non-nociceptive functions. The receptive properties of large myelinated afferent fibers were normal in p75-/- mice. However, the receptive properties of subpopulations of afferent fibers with thin myelinated or unmyelinated axons were strikingly impaired in mice lacking p75. Furthermore, the presence of p75 is required for normal mechanotransduction in C fibers and D-hair receptors and normal heat sensitivity in A-fiber nociceptors.
Indexed as
Identifiers
9151756PMC6573523W1844852786What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.