ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Vasopressin/serotonin interactions in the anterior hypothalamus control aggressive behavior in golden hamsters.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
154 citing papers in PubMed, 1 synthesis or guideline pooled it, 498 citations in OpenAlex.
- The effect of increased serotonergic neurotransmission on aggression: a critical meta-analytical review of preclinical studies.Psychopharmacology · 2009Pooled it
- A randomized placebo-controlled pilot trial shows that intranasal vasopressin improves social deficits in children with autism.Science translational medicine · 2019Trial
- A Single Dose, Randomized, Controlled Proof-Of-Mechanism Study of a Novel Vasopressin 1a Receptor Antagonist (RG7713) in High-Functioning Adults with Autism Spectrum Disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- Vasopressin Boosts Placebo Analgesic Effects in Women: A Randomized Trial.Biological psychiatry · 2016Trial
- Oxytocin and vasopressin receptor polymorphisms interact with circulating neuropeptides to predict human emotional reactions to stress.Emotion (Washington, D.C.) · 2014Trial
- Hypothalamic representation of aggressiveness across mouse strains.Nature communications · 2026Article
- Perspective for Modulation of Hypothalamic Neurogenesis: Integrating Anatomical Insights with Exercise and Dietary Interventions.International journal of molecular sciences · 2025Review
- Distinct subcircuits within the mesolimbic dopamine system encode the salience and valence of social stimuli.Psychopharmacology · 2025Article
- Article
- Social isolation induces sexually aggressive behaviour in male Wistar rats.BMC neuroscience · 2025Article
- The deletion of the arginine vasopressin 1a receptor impairs sexual and maternal behavior.Frontiers in endocrinology · 2025Article
- Brain receptor dynamics in early and adult life stress: Gateways to maladaptive coping strategies.Neurobiology of stress · 2025Review
- Article
- Sex differences in dominance relationships in Syrian hamsters.Physiology & behavior · 2023Article
- Anterior hypothalamic parvalbumin neurons are glutamatergic and promote escape behavior.Current biology : CB · 2023Article
- Comparing the ontogeny, neurobiology, and function of social play in hamsters and rats.Neuroscience and biobehavioral reviews · 2023Review
- The Role of Arginine-Vasopressin in Stroke and the Potential Use of Arginine-Vasopressin Type 1 Receptor Antagonists in Stroke Therapy: A Narrative Review.International journal of molecular sciences · 2023Review
- Modulation of social behavior by distinct vasopressin sources.Frontiers in endocrinology · 2023Review
- Sexual Dimorphism of Inputs to the Lateral Habenula in Mice.Neuroscience bulletin · 2022Article
- Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities.Endocrinology · 2022Review
94 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Studies in several species of rodents show that arginine vasopressin (AVP) acting through a V1A receptor facilitates offensive aggression, i.e., the initiation of attacks and bites, whereas serotonin (5-HT) acting through a 5-HT1B receptor inhibits aggressive responding. One area of the CNS that seems critical for the organization of aggressive behavior is the basolateral hypothalamus, particularly the anterior hypothalamic region. The present studies examine the neuroanatomical and neurochemical interaction between AVP and 5-HT at the level of the anterior hypothalamus (AH) in the control of offensive aggression in Syrian golden hamsters. First, specific V1A and 5-HT1B binding sites in the AH are shown by in vitro receptor autoradiography. The binding for each neurotransmitter colocalizes with a dense field of immunoreactive AVP and 5-HT fibers and putative terminals. Putative 5-HT synapses on AVP neurons in the area of the AH are identified by double-staining immunocytochemistry and laser scanning confocal microscopy. These morphological data predispose a functional interaction between AVP and 5-HT at the level of the AH. When tested for offensive aggression in a resident/intruder paradigm, resident hamsters treated with fluoxetine, a selective 5-HT reuptake inhibitor, have significantly longer latencies to bite and bite fewer times than vehicle-treated controls. Conversely, AVP microinjections into the AH significantly shorten the latency to bite and increase biting attacks. The action of microinjected AVP to increase offensive aggression is blocked by the pretreatment of hamsters with fluoxetine. These data suggest that 5-HT inhibits fighting, in part, by antagonizing the aggression-promoting action of the AVP system.
Indexed as
Identifiers
9151749PMC6573530W2157677118What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.