Evidence map›Paper›PMID 9151740›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997

A new form of inherited red-blindness identified in zebrafish.

S E Brockerhoff, J B Hurley, G A Niemi, J E Dowling

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 109 citations in OpenAlex.

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  13. Color Processing in Zebrafish Retina.Frontiers in cellular neuroscience · 2018
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

S E BrockerhoffDepartment of Molecular and Cellular Biology, The Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138, USA.
J B Hurley
G A Niemi
J E Dowling
Harvard University · USUniversity of Washington · US

Funding

ANATOMICAL AND BIOCHEMICAL ORGANIZATION OF THE RETINAR01EY000811 · NEI · HARVARD UNIVERSITY · PI DOWLING, JOHN E · 1985 to 2010
$5.2M
FUNCTIONAL ORGANIZATION OF VISUAL SYSTEMSR01EY000824 · NEI · HARVARD UNIVERSITY · PI DOWLING, JOHN E · 1985 to 2002
$1.0M
ANATOMICAL AND BIOCHEMICAL ORGANIZATION OF THE RETINAR37EY000811 · NEI · HARVARD UNIVERSITY · PI DOWLING, JOHN E · 1987 to 1996
–
NEI NIH HHS EY00811NEI NIH HHS EY00824NEI NIH HHS EY06762-01
6 · The paper itself

Abstract

A red-blind zebrafish mutant, partial optokinetic response b (pob), has been isolated by measuring eye movements of larvae in a three-generation screen for recessive mutations affecting the visual system. pob larvae exhibit eye movements in response to rotating black and white stripes illuminated with white light, but they do not move their eyes when the stripes are illuminated with red light. Physiological, immunohistochemical, and in situ hybridization analyses of pob retinas showed a selective loss of red-sensitive cones at 5 days postfertilization (dpf). At 3 dpf, cells expressing red opsin are present, suggesting that red-sensitive cones form initially but then disappear rapidly, whereas other photoreceptors remain. Linkage analysis indicated that the mutation identified in the pob mutant is not at the red opsin locus. Because red opsin is the only known molecule unique to red cones, these data suggest that a novel gene is required for the maintenance or function of red cones.

Indexed as

AnimalsBehavior, AnimalCell NucleusColor Vision DefectsGenotypeIn Situ HybridizationLarvaMutagenesisRetinal Cone Photoreceptor CellsRNA, MessengerRod OpsinsZebrafishlong-wavelength opsinRNA, MessengerRod Opsinsshort-wavelength opsin

Identifiers

PMID9151740
PMCPMC6573554
OpenAlexW2168441478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.