ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
The responses of rat trigeminal ganglion neurons to capsaicin and two nonpungent vanilloid receptor agonists, olvanil and glyceryl nonamide.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 105 citations in OpenAlex.
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- Cannabinoid Analgesia in Postoperative Pain Management: From Molecular Mechanisms to Clinical Reality.International journal of molecular sciences · 2024Review
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- Targeting Chemosensory Ion Channels in Peripheral Swallowing-Related Regions for the Management of Oropharyngeal Dysphagia.International journal of molecular sciences · 2020Review
- Combination of a Rapidly Penetrating Agonist and a Slowly Penetrating Antagonist Affords Agonist Action of Limited Duration at the Cellular Level.Biomolecules & therapeutics · 2019Article
- Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury.Annals of the New York Academy of Sciences · 2016Review
- Differential Activation of TRP Channels in the Adult Rat Spinal Substantia Gelatinosa by Stereoisomers of Plant-Derived Chemicals.Pharmaceuticals (Basel, Switzerland) · 2016Review
- Hypersensitivity Induced by Activation of Spinal Cord PAR2 Receptors Is Partially Mediated by TRPV1 Receptors.PloS one · 2016Article
- Photoswitchable fatty acids enable optical control of TRPV1.Nature communications · 2015Article
- Article
- Cannabinoid receptor antagonists AM251 and AM630 activate TRPA1 in sensory neurons.Neuropharmacology · 2011Article
- TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1.The European journal of neuroscience · 2009Article
- Role of ionotropic cannabinoid receptors in peripheral antinociception and antihyperalgesia.Trends in pharmacological sciences · 2009Review
- Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization.The Journal of physiology · 2007Article
- TRPV1 is a novel target for omega-3 polyunsaturated fatty acids.The Journal of physiology · 2007Article
- The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Comparison of P2X and TRPV1 receptors in ganglia or primary culture of trigeminal neurons and their modulation by NGF or serotonin.Molecular pain · 2006Article
- TRPV1 recapitulates native capsaicin receptor in sensory neurons in association with Fas-associated factor 1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Effect of olvanil and anandamide on vagal C-fiber subtypes in guinea pig lung.British journal of pharmacology · 2005Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Capsaicin, the pungent ingredient in hot pepper, activates and subsequently desensitizes a subset of polymodal nociceptors. Because its initial application to skin produces pain, nonpungent analogs such as olvanil and glyceryl nonivamide (GLNVA) were synthesized to enhance its clinical use. To explore how these nonpungent analogs differ from capsaicin, whole-cell patch-clamp recordings were performed on cultured rat trigeminal ganglion neurons. In neurons held at -60 mV, capsaicin, olvanil, and GLNVA were found to activate one or two kinetically distinct inward currents. Two inward currents were also activated when extracellular Ca2+ was replaced with Ba2+ and also when intracellular chloride was replaced by aspartate. The reversal potentials of the rapidly and slowly activating currents were 15.3 +/- 6 and -4.0 +/- 2.5 mV, respectively. These data provide strong evidence for subtypes of vanilloid receptors. One difference among these agonists is that, on average, the activation kinetics of the currents evoked by 1 microM olvanil and 30 microM GLNVA are considerably slower than those evoked by 1 microM capsaicin. Measurements of the peak current, Ip, versus agonist concentration were fit to the Hill equation to yield values of the half maximal concentrations (K1/2), and the Hill coefficients (n). For capsaicin, olvanil, and GLNVA, K1/2 = 0.68, 0.59, and 27.0 microM and n = 1.38, 1.32, and 1.24, respectively. We propose that olvanil and GLNVA are nonpungent because they activate different subtypes of receptors and/or because of their activation kinetics (compared with capsaicin) are, on average, slower than the rate they inhibit action potentials from polymodal nociceptors.
Indexed as
Identifiers
9151727PMC6573573W2132119503What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.