ArticleThe Journal of experimental medicine1997
Transforming growth factor beta (TGF-beta)-dependent inhibition of T helper cell 2 (Th2)-induced autoimmunity by self-major histocompatibility complex (MHC) class II-specific, regulatory CD4(+) T cell lines.
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 150 citations in OpenAlex.
- Regulatory T Cells Conditioned Media Stimulates Migration in HaCaT Keratinocytes: Involvement of Wound Healing.Clinical, cosmetic and investigational dermatology · 2020Article
- Assessment of soluble cytotoxic T lymphocyte-associated antigen-4, transforming growth factor βJournal of blood medicine · 2019Article
- Downregulation of TGF-β Receptor-2 Expression and Signaling through Inhibition of Na/K-ATPase.PloS one · 2016Article
- The correlation between plasma cytokine levels in jaundice-free children with biliary atresia.World journal of pediatrics : WJP · 2015Article
- RFXB and its splice variant RFXBSV mediate the antagonism between IFNgamma and TGFbeta on COL1A2 transcription in vascular smooth muscle cells.Nucleic acids research · 2009Article
- Brothers and sisters: molecular insights into arterial-venous heterogeneity.Circulation research · 2008Review
- Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.Japanese journal of clinical oncology · 2008Article
- Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- T cell regulation as a side effect of homeostasis and competition.The Journal of experimental medicine · 2003Article
- Development of CD4+ T cell lines that suppress an antigen-specific immune response in vivo.Clinical and experimental immunology · 2003Article
- Modulation of a heterologous immune response by the products of Ascaris suum.Infection and immunity · 2002Article
- Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Tr1 cell-dependent active tolerance blunts the pathogenic effects of determinant spreading.The Journal of clinical investigation · 2002Article
- In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.The Journal of experimental medicine · 2002Article
- Analysis of mercury-induced immune activation in nonobese diabetic (NOD) mice.Clinical and experimental immunology · 2001Article
- Suppressor T cells regulate the nonanergic cell population that remains after peripheral tolerance is induced to the Mls-1 antigen in T cell receptor Vbeta 8.1 transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Anti-interleukin 10 receptor monoclonal antibody is an adjuvant for T helper cell type 1 responses to soluble antigen only in the presence of lipopolysaccharide.The Journal of experimental medicine · 2000Article
- Exogenous type-1 cytokines modulate mercury-induced hyper-IgE in the rat.Clinical and experimental immunology · 2000Article
- CD4(+) T helper cells engineered to produce latent TGF-beta1 reverse allergen-induced airway hyperreactivity and inflammation.The Journal of clinical investigation · 2000Article
- An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation.The Journal of experimental medicine · 1999Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autoreactive anti-MHC class II T cells are found in Brown Norway (BN) and Lewis (LEW) rats that receive either HgCl2 or gold salts. These T cells have a T helper cell 2 (Th2) phenotype in the former strain and are responsible for Th2-mediated autoimmunity. In contrast, T cells that expand in LEW rats produce IL-2 and prevent experimental autoimmune encephalomyelitis, a cell-mediated autoimmune disease. The aim of this work was to investigate, using T cell lines derived from HgCl2-injected LEW rats (LEWHg), the effect of these autoreactive T cells on the development of Th2-mediated autoimmunity. The five LEWHg T cell lines obtained protect against Th2-mediated autoimmunity induced by HgCl2 in (LEW x BN)F1 hybrids. The lines produce, in addition to IL-2, IFN-gamma and TGF-beta, and the protective effect is TGF-beta dependent since protection is abrogated by anti-TGF-beta treatment. These results identify regulatory, TGF-beta-producing, autoreactive T cells that are distinct from classical Th1 or Th2 and inhibit both Th1- and Th2-mediated autoimmune diseases.
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