ArticleJournal of bacteriology1997
An alkB gene homolog is differentially transcribed during the Caulobacter crescentus cell cycle.
Article in Journal of bacteriology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Comparison of CcrM-dependent methylation inJournal of bacteriology · 2024Article
- Comparison of CcrM-dependent methylation inbioRxiv : the preprint server for biology · 2024Article
- Widespread prevalence of a methylation-dependent switch to activate an essential DNA damage response in bacteria.PLoS biology · 2024Article
- Mechanistic insight into the repair of C8-linked pyrrolobenzodiazepine monomer-mediated DNA damage.RSC medicinal chemistry · 2022Article
- Hoogsteen base pairs increase the susceptibility of double-stranded DNA to cytotoxic damage.The Journal of biological chemistry · 2020Article
- Occurrence and repair of alkylating stress in the intracellular pathogen Brucella abortus.Nature communications · 2019Article
- Nucleic acid oxidation in DNA damage repair and epigenetics.Chemical reviews · 2014Review
- Genome analysis of DNA repair genes in the alpha proteobacterium Caulobacter crescentus.BMC microbiology · 2007Article
- Oxidative dealkylation DNA repair mediated by the mononuclear non-heme iron AlkB proteins.Journal of inorganic biochemistry · 2006Review
- Direct reversal of DNA alkylation damage.Chemical reviews · 2006Review
- Review
- Conserved gene cluster at replication origins of the alpha-proteobacteria Caulobacter crescentus and Rickettsia prowazekii.Journal of bacteriology · 2001Article
- Defective processing of methylated single-stranded DNA by E. coli AlkB mutants.Genes & development · 2000Article
- Identification of a regulator that controls stationary-phase expression of catalase-peroxidase in Caulobacter crescentus.Journal of bacteriology · 1999Article
- Catalase-peroxidase of Caulobacter crescentus: function and role in stationary-phase survival.Journal of bacteriology · 1997Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A Caulobacter crescentus alkB gene homolog was identified in a clone previously shown to contain the heat shock genes dnaK and dnaJ; the homolog is located upstream of dnaK and is transcribed in the opposite orientation. An analysis of the alkB gene has shown that the deduced amino acid sequence is that of a 21-kDa protein, which is 42% identical and 78% similar to Escherichia coli AlkB. Furthermore, an alkB-null mutant was constructed by gene disruption and was shown to be highly sensitive to the alkylating agent methyl methanesulfonate (MMS). However, the alkB gene of C. crescentus, unlike its E. coli counterpart, is not located downstream of the ada gene, and its transcription is not induced by alkylating agents. In addition, no acquired enhanced resistance to MMS toxicity by treatment with low MMS doses was observed, suggesting that no adaptive response occurs in C. crescentus. Nevertheless, transcription of the alkB gene is cell cycle controlled, with a pattern of expression similar to that of several Caulobacter genes involved in DNA replication.
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