ArticleJournal of bacteriology1997
comYA, a gene similar to comGA of Bacillus subtilis, is essential for competence-factor-dependent DNA transformation in Streptococcus gordonii.
Article in Journal of bacteriology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Inhibitory effect of surface pre-reacted glass-ionomer (S-PRG) eluate against adhesion and colonization by Streptococcus mutans.Scientific reports · 2018Article
- Hydrogen peroxide-dependent DNA release and transfer of antibiotic resistance genes in Streptococcus gordonii.Journal of bacteriology · 2011Article
- Genome-wide transcriptional changes in Streptococcus gordonii in response to competence signaling peptide.Journal of bacteriology · 2007Article
- Competence-dependent bacteriocin production by Streptococcus gordonii DL1 (Challis).Journal of bacteriology · 2007Article
- Biology of Pseudomonas stutzeri.Microbiology and molecular biology reviews : MMBR · 2006Review
- DNA binding-uptake system: a link between cell-to-cell communication and biofilm formation.Journal of bacteriology · 2005Article
- Natural transformation of Campylobacter jejuni requires components of a type II secretion system.Journal of bacteriology · 2003Article
- Growth, development, and gene expression in a persistent Streptococcus gordonii biofilm.Infection and immunity · 2003Article
- Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Differential recognition of surface proteins in Streptococcus pyogenes by two sortase gene homologs.Journal of bacteriology · 2002Article
- Diversity of Tn4001 transposition products: the flanking IS256 elements can form tandem dimers and IS circles.Journal of bacteriology · 2002Article
- Pseudomonas stutzeri has two closely related pilA genes (Type IV pilus structural protein) with opposite influences on natural genetic transformation.Journal of bacteriology · 2001Article
- Natural genetic transformation of Streptococcus mutans growing in biofilms.Journal of bacteriology · 2001Article
- Type IV pilus genes pilA and pilC of Pseudomonas stutzeri are required for natural genetic transformation, and pilA can be replaced by corresponding genes from nontransformable species.Journal of bacteriology · 2000Article
- Construction and analysis of a library for random insertional mutagenesis in Streptococcus pneumoniae: use for recovery of mutants defective in genetic transformation and for identification of essential genes.Applied and environmental microbiology · 1999Article
- Insertional inactivation of genes responsible for the D-alanylation of lipoteichoic acid in Streptococcus gordonii DL1 (Challis) affects intrageneric coaggregations.Infection and immunity · 1999Article
- A role for trigger factor and an rgg-like regulator in the transcription, secretion and processing of the cysteine proteinase of Streptococcus pyogenes.The EMBO journal · 1998Article
- Adherence of the gram-positive bacterium Ruminococcus albus to cellulose and identification of a novel form of cellulose-binding protein which belongs to the Pil family of proteins.Journal of bacteriology · 1998Article
- All seven comG open reading frames are required for DNA binding during transformation of competent Bacillus subtilis.Journal of bacteriology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tn4001 mutagenesis identified a new competence gene in Streptococcus gordonii Challis designated comYA. A comYA mutant was completely deficient in transformation and exhibited decreased levels of DNA binding and hydrolysis. The deduced 319-amino-acid ComYA protein exhibited 57% similarity and 33% identity to the ComGA transporter protein of Bacillus subtilis and contained the Walker A-box motif conserved in ATP-binding proteins as well as aspartic acid boxes Asp-1 and Asp-2 present in some components of the general secretory pathway of gram-negative bacteria. comYA appeared to be part of a putative operon encompassing a comGB homolog, designated comYB, together with sequences that could encode ComGC- and ComGD-like peptides designated ComYC and ComYD, respectively, as well as other components. The putative ComYC and ComYD peptides had leader sequences similar to the type IV N-methylphenylalanine pilins of gram-negative bacteria, but unlike other examples in this class, including B. subtilis, they contained an alanine at position -1 of the leader instead of the usual glycine residue. Northern analysis identified a single 6.0-kb comYA-containing transcript strictly dependent on exogenous competence factor for expression in ComA1 cells. An identical pattern of expression was seen in wild-type Challis cells grown under conditions of maximal competence but not in cells that were noncompetent.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.