ArticleAmerican journal of human genetics1997
A genomewide linkage study of preeclampsia/eclampsia reveals evidence for a candidate region on 4q.
Article in American journal of human genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Heterogeneity-based genome search meta-analysis for preeclampsia.Human genetics · 2006Pooled it
- Identification of complement factor H variants that predispose to pre-eclampsia: A genetic and functional study.BJOG : an international journal of obstetrics and gynaecology · 2023Article
- miR-30a targets STOX2 to increase cell proliferation and metastasis in hydatidiform moles via ERK, AKT, and P38 signaling pathways.Cancer cell international · 2022Article
- Genetic variation in placental insufficiency: What have we learned over time?Frontiers in cell and developmental biology · 2022Review
- Dysfunction of complement receptors CR3 (CD11b/18) and CR4 (CD11c/18) in pre-eclampsia: a genetic and functional study.BJOG : an international journal of obstetrics and gynaecology · 2021Article
- Association of preeclampsia with infant APOL1 genotype in African Americans.BMC medical genetics · 2020Article
- Analysis of the Epigenome in Multiplex Pre-eclampsia Families IdentifiesFrontiers in genetics · 2019Article
- Noncoding RNA-regulated gain-of-function of STOX2 in Finnish pre-eclamptic families.Scientific reports · 2016Article
- Exome sequencing in pooled DNA samples to identify maternal pre-eclampsia risk variants.Scientific reports · 2016Article
- Article
- A follow-up linkage study of Finnish pre-eclampsia families identifies a new fetal susceptibility locus on chromosome 18.European journal of human genetics : EJHG · 2013Article
- STOX1: Key player in trophoblast dysfunction underlying early onset preeclampsia with growth retardation.Journal of pregnancy · 2011Review
- STOX2 but not STOX1 is differentially expressed in decidua from pre-eclamptic women: data from the Second Nord-Trondelag Health Study.Molecular human reproduction · 2010Article
- Article
- Association between the candidate susceptibility gene ACVR2A on chromosome 2q22 and pre-eclampsia in a large Norwegian population-based study (the HUNT study).European journal of human genetics : EJHG · 2009Article
- Genetics of preeclampsia: paradigm shifts.Human genetics · 2007Review
- Susceptibility loci for preeclampsia on chromosomes 2p25 and 9p13 in Finnish families.American journal of human genetics · 2003Article
- Polymorphism in the tumor necrosis factor-alpha gene in women with preeclampsia.Journal of assisted reproduction and genetics · 2002Article
- Genomewide scans of complex human diseases: true linkage is hard to find.American journal of human genetics · 2001Article
- A genome scan in families from Australia and New Zealand confirms the presence of a maternal susceptibility locus for pre-eclampsia, on chromosome 2.American journal of human genetics · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preeclampsia (PE) and eclampsia (E) are potentially life-threatening conditions that can occur during human pregnancy. Generally considered to be different degrees of severity of the same disease process, the PE/E syndrome is thought to be predominantly genetic in origin, although its exact etiology and genetics are not fully understood. Here we report results of a genomewide linkage search for the gene(s) responsible for susceptibility to PE/E, using 15 informative pedigrees and 90 polymorphic DNA markers from all autosomes. Because of uncertainties concerning inheritance and diagnosis, four different models that assume maternal gene expression have been used to carry out LOD-score analysis. The region between D4S450 and D4S610 (2.8 cM) on the long arm of chromosome 4 was identified as a strong candidate region for a PE/E-susceptibility locus. The maximum multipoint LOD score within this interval was 2.9. Analysis of markers in the region around D4S450 and D4S610 by the affected-pedigree-member method also supported the possibility of a susceptibility locus in this region. However, to verify or exclude definitively linkage to this region, other groups of PE/E pedigrees will be required.
Indexed as
Identifiers
9150163PMC1712421What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.