ArticleAmerican journal of human genetics1997
A low proportion of BRCA2 mutations in Finnish breast cancer families.
Article in American journal of human genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Estrogen receptor genes variations and breast cancer risk in Iran.International journal of clinical and experimental medicine · 2012Article
- Genetic anticipation is associated with telomere shortening in hereditary breast cancer.PLoS genetics · 2011Article
- Estrogen receptor-beta gene polymorphism in women with breast cancer at the Imam Khomeini Hospital Complex, Iran.BMC medical genetics · 2010Article
- Basal cytokeratins in breast tumours among BRCA1, BRCA2 and mutation-negative breast cancer families.Breast cancer research : BCR · 2008Article
- Histopathological features of breast tumours in BRCA1, BRCA2 and mutation-negative breast cancer families.Breast cancer research : BCR · 2005Article
- Relationship of patients' age to histopathological features of breast tumours in BRCA1 and BRCA2 and mutation-negative breast cancer families.Breast cancer research : BCR · 2005Article
- Mutation analysis of the CHK2 gene in families with hereditary breast cancer.British journal of cancer · 2001Article
- A probability model for predicting BRCA1 and BRCA2 mutations in breast and breast-ovarian cancer families.British journal of cancer · 2001Article
- Analysis of autism susceptibility gene loci on chromosomes 1p, 4p, 6q, 7q, 13q, 15q, 16p, 17q, 19q and 22q in Finnish multiplex families.Molecular psychiatry · 2000Article
- Identification of a founder BRCA2 mutation in Sardinia.British journal of cancer · 2000Article
- Founder populations and their uses for breast cancer genetics.Breast cancer research : BCR · 2000Review
- Screening for BRCA2 mutations in 81 Dutch breast-ovarian cancer families.British journal of cancer · 2000Article
- Founder BRCA1 and BRCA2 mutations in French Canadian breast and ovarian cancer families.American journal of human genetics · 1998Article
- The genetics of inherited breast cancer.Journal of mammary gland biology and neoplasia · 1998Review
- A population study of mutations and LOH at breast cancer gene loci in tumours from sister pairs: two recurrent mutations seem to account for all BRCA1/BRCA2 linked breast cancer in Iceland.Journal of medical genetics · 1998Article
- A missense mutation in the BRCA2 gene in three siblings with ovarian cancer.British journal of cancer · 1998Article
- Determining carrier probabilities for breast cancer-susceptibility genes BRCA1 and BRCA2.American journal of human genetics · 1998Article
- Population genetics of BRCA1 and BRCA2.American journal of human genetics · 1997Article
- BRCA2 mutations in 154 finnish male breast cancer patients.Neoplasia (New York, N.Y.)Article
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Abstract
One hundred breast cancer families were identified at the Helsinki University Central Hospital in Finland and were screened for germ-line mutations in the coding regions and splice boundaries of the BRCA2 gene. Eight families (8%) were found to carry five different mutations, all of which are predicted to prematurely truncate the protein product. These BRCA2 families have early-onset breast cancer (mean and median age = 49 years), with four of the eight families including ovarian cancer but with no families including male breast cancer. A wide spectrum of other cancers also is seen in these families. Three mutations were identified in more than one family, and haplotype analysis in the families suggested a common founder for each recurrent mutation. One recurrent mutation, 999del5, previously has been noted as a common mutation in Iceland. The relationship between the Icelandic 999del5 mutation and the Finnish 999del5 mutation was explored by comparison of families from both countries. A common haplotype covering a minimal region intragenic to the BRCA2 gene was shared between the Icelandic and the Finnish mutation carriers.
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