ArticleDigestive diseases and sciences1997
Adaptation of esophageal mucosa to acid- and pepsin-induced damage: role of nitric oxide and epidermal growth factor.
Article in Digestive diseases and sciences, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Acid challenge to the human esophageal mucosa: effects on epithelial architecture in health and disease.Digestive diseases and sciences · 2005Trial
- Acid challenge to the esophageal mucosa: effects on local nitric oxide formation and its relation to epithelial functions.Digestive diseases and sciences · 2005Trial
- Topical Alginate Protection against Pepsin-Mediated Esophageal Damage: E-Cadherin Proteolysis and Matrix Metalloproteinase Induction.International journal of molecular sciences · 2023Article
- Gaseous mediators nitric oxide and hydrogen sulfide in the mechanism of gastrointestinal integrity, protection and ulcer healing.Molecules (Basel, Switzerland) · 2015Review
- From reflux esophagitis to Barrett's esophagus and esophageal adenocarcinoma.World journal of gastroenterology · 2015Review
- Ischemic heart disease, factor predisposing to Barrett's adenocarcinoma: A case control study.World journal of gastrointestinal pharmacology and therapeutics · 2014Article
- Animal model of acid-reflux esophagitis: pathogenic roles of acid/pepsin, prostaglandins, and amino acids.BioMed research international · 2014Review
- Orally administered L-arginine and glycine are highly effective against acid reflux esophagitis in rats.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- ERBBs in the gastrointestinal tract: recent progress and new perspectives.Experimental cell research · 2009Review
- Minimal changes in reflux esophagitis: red ones and white ones.Journal of gastroenterology · 2006Review
- Essential role of pepsin in pathogenesis of acid reflux esophagitis in rats.Digestive diseases and sciences · 2006Article
- Reflux laryngitis in a patient with Zollinger Ellison syndrome and the role of epidermal growth factor.Digestive diseases and sciences · 2004Article
- Superoxide anion and nitric oxide in high-grade esophagitis induced by acid and pepsin in rabbits.Digestive diseases and sciences · 2001Article
- Oxidative stress is more important than acid in the pathogenesis of reflux oesophagitis in rats.Gut · 2001Article
- Nitric oxide and superoxide anion in low-grade esophagitis induced by acid and pepsin in rabbits.Digestive diseases and sciences · 2000Article
- Pepsin and the esophagus.The Yale journal of biology and medicineReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To study whether the esophageal mucosa was able to elicit mucosal adaptation, we induced esophageal damage by perfusing acidified pepsin in rabbits. Mucosal adaptation was induced by preexposing the esophageal mucosa to a mild irritant (acidified saline) for 60 min prior to acidified pepsin (strong irritant). Macroscopic and microscopic esophageal injury, cell proliferation, and mucosal barrier function (H+, K+, hemoglobin flux rates) were studied. Preexposure of the esophageal mucosa to acidified saline significantly decreased both the mucosal damage and the mucosal barrier dysfunction induced by acidified pepsin. The development of this phenomenon was nondependent on cell proliferation. Concomitant treatment with either the nitric oxide synthase inhibitor, N(G)-nitro-L-arginine, or the perfusion of immunospecific EGF-receptor antibodies or tyrphostin-25, an inhibitor of the tyrosine kinase activities ligated to the intracytoplasmatic domain of the EGF receptor, during the preexposure period completely reversed the protection induced by acid. We conclude that the rabbit esophageal mucosa shows mucosal adaptation to acid and pepsin. The development of this phenomenon is fast, not dependent on cell proliferation, and dependent, at least in part, on nitric oxide and EGF-receptor-mediated mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.