ArticleJournal of anatomy1997
The effects of ageing on wound healing: immunolocalisation of growth factors and their receptors in a murine incisional model.
Article in Journal of anatomy, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 110 citations in OpenAlex.
- Characterization and Physiological Differences of Two Primary Cultures of Human Normal and Hypertrophic Scar Dermal Fibroblasts: A Pilot Study.Biomedicines · 2024Article
- The pathophysiology of chronic subdural hematoma revisited: emphasis on aging processes as key factor.GeroScience · 2022Review
- Age-associated impairments in tissue strength and immune response in a rat vaginal injury model.International urogynecology journal · 2020Article
- Conditional knockout of N-WASP in mouse fibroblast caused keratinocyte hyper proliferation and enhanced wound closure.Scientific reports · 2016Article
- 17β-Estradiol administration promotes delayed cutaneous wound healing in 40-week ovariectomised female mice.International wound journal · 2016Article
- The effect ofIranian journal of basic medical sciences · 2016Article
- Lidocaine Impairs Proliferative and Biosynthetic Functions of Aged Human Dermal Fibroblasts.Anesthesia and analgesia · 2016Article
- Cellular and Molecular Responses to Mechanical Expansion of Tissue.Frontiers in physiology · 2016Review
- Anesthesia, microcirculation, and wound repair in aging.Anesthesiology · 2014Review
- Evaluation of effect of oleuropein on skin wound healing in aged male BALB/c mice.Cell journal · 2014Article
- Pistacia atlantica Resin Has a Dose-Dependent Effect on Angiogenesis and Skin Burn Wound Healing in Rat.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- A Comparison Study of Growth Factor Expression following Treatment with Transcutaneous Electrical Nerve Stimulation, Saline Solution, Povidone-Iodine, and Lavender Oil in Wounds Healing.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Transplanted fibroblasts prevents dysfunctional repair in a murine CXCR3-deficient scarring model.Cell transplantation · 2012Article
- Transient supplementation of anabolic growth factors rapidly stimulates matrix synthesis in engineered cartilage.Annals of biomedical engineering · 2011Article
- [Dermatoendocrinology. Skin aging].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2010Review
- Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration.Journal of the Royal Society, Interface · 2007Review
- Risk factors related to recurrence in inguinal hernia repair: a retrospective analysis.Hernia : the journal of hernias and abdominal wall surgery · 2006Article
- Immunosenescence and macrophage functional plasticity: dysregulation of macrophage function by age-associated microenvironmental changes.Immunological reviews · 2005Review
- Scar-free healing: from embryonic mechanisms to adult therapeutic intervention.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2004Review
- [Possible interventions in impaired wound healing].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A number of reports suggest that the process of ageing impairs wound repair and that strategies to manipulate the age-related wound healing environment are necessary in order to stimulate repair. The process of cutaneous wound repair is controlled by growth factors in an autocrine and paracrine fashion: it is therefore surprising that the localisation of specific growth factors and their receptors has not been documented in wound healing with respect to chronological age. In this study the temporal profile of growth factor and receptor immunostaining was assessed within acute incisional wounds in an ageing mouse colony. A delay in appearance of platelet derived growth factor (PDGF) A and B isoforms, and PDGF-alpha and -beta receptors was evident with increasing animal age, paralleled by a similar finding for epidermal growth factor (EGF) and EGF receptor. Transforming growth factor (TGF)-beta 1 and 2 isoforms were increased at all time points in the wounds of younger animals, but the TGF-beta 3 isoform increased in intensity from d 7 postwounding in the old mice wounds, and basic fibroblast growth factor (bFGF) from d 14. The quantity and distribution patterns of the various growth factors and their receptors may explain the age-related differences in wound healing speed and quality, and possibly suggest new therapeutic targets for manipulating wound healing in the aged.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.