ArticleClinical and diagnostic laboratory immunology1997
Modulatory effect of mycobacterium cell wall extract (Regressin) on lymphocyte blastogenic activity and macrophage cytokine gene transcription in swine.
Article in Clinical and diagnostic laboratory immunology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 11 citations in OpenAlex.
- Effect of peripartal administration of mycobacterium cell wall fraction on health and fertility of Holstein cows under organic-certified management.Journal of animal science · 2021Article
- Effects of the Administration of a Non-specific Immune Stimulant Around Transportation on Health and Performance of Jersey and Jersey-Cross Heifer Calves During the Rearing Period: Randomized Clinical Trial.Frontiers in veterinary science · 2020Article
- The effect of natural adjuvants on pathological changes in sensitized Guinea pig lungs.Iranian Red Crescent medical journal · 2014Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycobacterium cell wall extract (MCWE) (Regressin) contains trehalose dimycolate and muramyl dipeptide, both of which have immunomodulatory properties. The goal of this study was to evaluate the effect of MCWE on the in vitro peripheral blood lymphocyte blastogenic activities to mitogens phytohemagglutinin (PHA) and concanavalin A (ConA) in 6- to 8-week-old piglets. The effect of MCWE on alveolar macrophage tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta) gene transcription, as determined by a reverse transcription-PCR assay standardized with the endogenous glyceraldehyde-3-phosphate dehydrogenase gene, was also investigated. The results show enhanced blastogenic lymphocyte activities to mitogens PHA and ConA in MCWE-exposed cell cultures compared to those of control cell cultures. The enhanced blastogenic activity effect of MCWE was dose dependent. The cell background activity (spontaneous [3H]thymidine incorporation) of lymphocyte cultures was also significantly increased in the presence of MCWE, thereby demonstrating a lymphocyte mitogenic effect of MCWE. Cytokine gene transcription analysis showed that the TNF-alpha transcript levels in alveolar macrophage cell cultures stimulated with MCWE for 6 or 16 h were enhanced compared with those in control cell cultures. An enhancement of IL-1beta mRNA levels in cell cultures stimulated for 16 h with MCWE, compared with those in control cell cultures, was also observed. The overall results demonstrate that MCWE can stimulate lymphocyte functional activity and cytokine mRNA expression in swine, thereby indicating its potential use as a clinical immunotherapeutic agent.
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