ArticleProceedings of the National Academy of Sciences of the United States of America1997
Comparison of parametric and nonparametric methods to map oligogenes by linkage.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- A first trial of retrospective collaboration for positional cloning in complex inheritance: assay of the cytokine region on chromosome 5 by the consortium on asthma genetics (COAG).Proceedings of the National Academy of Sciences of the United States of America · 2000Trial
- A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics.American journal of human genetics · 2005Article
- Confirmation of chromosome 7q11 locus for predisposition to intracranial aneurysm.Human genetics · 2004Article
- Pseudoautosomal linkage of Hodgkin disease.American journal of human genetics · 1999Article
- Analysis of affected sib pairs, with covariates--with and without constraints.American journal of human genetics · 1999Article
- Tests and estimates of allelic association in complex inheritance.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Allelic association under map error and recombinational heterogeneity: a tale of two sites.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Significance levels in complex inheritance.American journal of human genetics · 1998Article
- Mapping a disease locus by allelic association.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A sample of 95 sib pairs affected with insulin-dependent diabetes and typed with their normal parents for 28 markers on chromosome 6 has been analyzed by several methods. When appropriate parameters are efficiently estimated, a parametric model is equivalent to the beta model, which is superior to nonparametric alternatives both in single point tests (as found previously) and in multipoint tests. Theory is given for meta-analysis combined with allelic association, and problems that may be associated with errors of map location and/or marker typing are identified. Reducing by multipoint analysis the number of association tests in a dense map can give a 3-fold reduction in the critical lod, and therefore in the cost of positional cloning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.