ArticleProceedings of the National Academy of Sciences of the United States of America1997
Mapmodulin: a possible modulator of the interaction of microtubule-associated proteins with microtubules.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 55 citations in OpenAlex.
- Acidic nuclear phosphoprotein 32A (ANP32A): structure, function, and its role in disease pathogenesis.Molecular biology reports · 2026Review
- Cracking the ANP32 whips: important functions, unequal requirement, and hints at disease implications.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Article
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- LANP mediates neuritic pathology in Spinocerebellar ataxia type 1.Neurobiology of disease · 2012Article
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- Cpd-1 null mice display a subtle neurological phenotype.PloS one · 2010Article
- The Syk kinase SmTK4 of Schistosoma mansoni is involved in the regulation of spermatogenesis and oogenesis.PLoS pathogens · 2010Article
- I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A.The Journal of biological chemistry · 2008Article
- The crystal structure of the tumor suppressor protein pp32 (Anp32a): structural insights into Anp32 family of proteins.Protein science : a publication of the Protein Society · 2007Article
- The role of LANP and ataxin 1 in E4F-mediated transcriptional repression.EMBO reports · 2007Article
- Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes.The EMBO journal · 2004Article
- Generation and characterization of LANP/pp32 null mice.Molecular and cellular biology · 2004Article
- Anp32e (Cpd1) and related protein phosphatase 2 inhibitors.Cerebellum (London, England) · 2003Review
- Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery.Journal of virology · 2002Article
- Evidence of a role for nonmuscle myosin II in herpes simplex virus type 1 egress.Journal of virology · 2002Article
- Protein ligands to HuR modulate its interaction with target mRNAs in vivo.The Journal of cell biology · 2000Article
- Mapmodulin, cytoplasmic dynein, and microtubules enhance the transport of mannose 6-phosphate receptors from endosomes to the trans-golgi network.Molecular biology of the cell · 1999Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have purified and characterized a 31-kDa protein named mapmodulin that binds to the microtubule-associated proteins (MAPs) MAP2, MAP4, and tau. Mapmodulin binds free MAPs in strong preference to microtubule-associated MAPs, and appears to do so via the MAP's tubulin-binding domain. Mapmodulin inhibits the initial rate of MAP2 binding to microtubules, a property that may allow mapmodulin to displace MAPs from the path of organelles translocating along microtubules. In support of this possibility, mapmodulin stimulates the microtubule- and dynein-dependent localization of Golgi complexes in semi-intact CHO cells. To our knowledge, mapmodulin represents the first example of a protein that can bind and potentially regulate multiple MAP proteins.
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Registered trials
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