ArticleBiophysical journal1997
Measurements of Ca2+ entry and sarcoplasmic reticulum Ca2+ content during the cardiac cycle in guinea pig and rat ventricular myocytes.
Article in Biophysical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 64 citations in OpenAlex.
- Mitochondrial Membrane Intracellular Communication in Healthy and Diseased Myocardium.Frontiers in cell and developmental biology · 2020Review
- Species-Dependent Mechanisms of Cardiac Arrhythmia: A Cellular Focus.Clinical Medicine Insights. Cardiology · 2017Review
- Therapeutic cardiac-targeted delivery of miR-1 reverses pressure overload-induced cardiac hypertrophy and attenuates pathological remodeling.Journal of the American Heart Association · 2013Article
- Regulation of ion gradients across myocardial ischemic border zones: a biophysical modelling analysis.PloS one · 2013Article
- Quantification of calcium entry at the T-tubules and surface membrane in rat ventricular myocytes.Biophysical journal · 2006Article
- Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (I(to)).The Journal of physiology · 2003Review
- Pumps and leaks in the heart.The Journal of physiology · 2002Article
- Alterations in action potential profile enhance excitation-contraction coupling in rat cardiac myocytes.The Journal of physiology · 2001Article
- Inhibition of Ca(2+) sparks by ruthenium red in permeabilized rat ventricular myocytes.Biophysical journal · 2000Article
- Ca2+-activated non-selective cation current in rabbit ventricular myocytes.The Journal of physiology · 2000Article
- Tetracaine can inhibit contractions initiated by a voltage-sensitive release mechanism in guinea-pig ventricular myocytes.The Journal of physiology · 1999Article
- Relationship between transient outward K+ current and Ca2+ influx in rat cardiac myocytes of endo- and epicardial origin.The Journal of physiology · 1999Article
- Na+-Ca2+ exchange and sarcoplasmic reticular Ca2+ regulation in ventricular myocytes from transgenic mice overexpressing the Na+-Ca2+ exchanger.The Journal of physiology · 1998Article
- Control of maximum sarcoplasmic reticulum Ca load in intact ferret ventricular myocytes. Effects Of thapsigargin and isoproterenol.The Journal of general physiology · 1998Article
- Mitochondrial calcium in relaxed and tetanized myocardium.Biophysical journal · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigates the contribution of Ca2+ entry via sarcolemmal (SL) Ca2+ channels to the Ca2+ transient and its relationship with sarcoplasmic reticulum (SR) Ca2+ content during steady-state contraction in guinea pig and rat ventricular myocytes. The action potential clamp technique was used to obtain physiologically relevant changes in membrane potential. A method is shown that allows calculation of Ca2+ entry through the SL Ca2+ channels by measuring Cd(2+)-sensitive current during the whole cardiac cycle. SR Ca2+ content was calculated from caffeine-induced transient inward current. In guinea pig cardiac myocytes stimulated at 0.5 Hz and 0.2 Hz, Ca2+ entry through SL Ca2+ channels during a cardiac cycle was approximately 30% and approximately 50%, respectively, of the SR Ca2+ content. In rat myocytes Ca2+ entry via SL Ca2+ channels at 0.5 Hz was approximately 3.5% of the SR Ca2+ content. In the presence of 500 nM thapsigargin Ca2+ entry via SL Ca2+ channels in guinea pig cardiac cells was 39% greater than in controls, suggesting a larger contribution of this mechanism to the Ca2+ transient when the SR is depleted of Ca2+. These results provide quantitative support to the understanding of the relationship between Ca2+ entry and the SR Ca2+ content and may help to explain differences in the Ca2+ handling observed in different species.
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