ArticleBiophysical journal1997
Noise analysis of ion channels in non-space-clamped cables: estimates of channel parameters in olfactory cilia.
Article in Biophysical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- Olfactory cilia, regulation and control of olfaction.Physiological reports · 2024Review
- Low signaling efficiency from receptor to effector in olfactory transduction: A quantified ligand-triggered GPCR pathway.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The cyclic AMP signaling pathway in the rodent main olfactory system.Cell and tissue research · 2021Review
- The long tale of the calcium activated ClChannels (Austin, Tex.) · 2017Review
- Single Ca(2+)-activated Cl(-) channel currents recorded from toad olfactory cilia.BMC neuroscience · 2016Article
- Article
- High glutamate permeability and distal localization of Best1 channel in CA1 hippocampal astrocyte.Molecular brain · 2013Article
- 2,4,6-trichloroanisole is a potent suppressor of olfactory signal transduction.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Ca2+-activated Cl- channels of the ClCa family express in the cilia of a subset of rat olfactory sensory neurons.PloS one · 2013Article
- Article
- Mechanism of olfactory masking in the sensory cilia.The Journal of general physiology · 2009Article
- First Contact to Odors: Our Current Knowledge about Odorant Receptor.Sensors (Basel, Switzerland) · 2008Review
- Distribution, amplification, and summation of cyclic nucleotide sensitivities within single olfactory sensory cilia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Identification of Cl(Ca) channel distributions in olfactory cilia.Mathematical methods in the applied sciences · 2008Article
- Recording, analysis, and function of dendritic voltage-gated channels.Pflugers Archiv : European journal of physiology · 2006Review
- Bestrophin-2 is a candidate calcium-activated chloride channel involved in olfactory transduction.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Clustering of cyclic-nucleotide-gated channels in olfactory cilia.Biophysical journal · 2006Article
- Numerical Approximation of Solutions of a Nonlinear Inverse Problem Arising in Olfaction Experimentation.Mathematical and computer modelling · 2006Article
- Model of calcium oscillations due to negative feedback in olfactory cilia.Biophysical journal · 2006Article
- Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Ion channels in the cilia of olfactory neurons are part of the transduction machinery of olfaction. Odorant stimuli have been shown to induce a biphasic current response, consisting of a cAMP-activated current and a Ca(2+)-activated Cl- current. We have developed a noise analysis method to study ion channels in leaky cables, such as the olfactory cilium, under non-space-clamp conditions. We performed steady-state noise analysis on ligand-induced currents in excised cilia, voltage-clamped at input and internally perfused with cAMP or Ca2+. The cAMP-activated channels analyzed by this method gave results similar to those of single-channel recordings (gamma = 8.3 pS). Single-channel currents have not yet been recorded for the Ca(2+)-activated Cl- channels. Using our noise analysis method, we estimate a unit conductance, gamma = 0.8 pS, for these channels. The density of channels was found to be approximately 70 channels/micron2 for both channel species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.