ArticleThe American journal of pathology1997
ICAM-1-mediated adhesion of peripheral blood monocytes to the maternal surface of placental syncytiotrophoblasts: implications for placental villitis.
Article in The American journal of pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Is Toxoplasma gondii type related to clinical outcome in human congenital infection? Systematic and critical review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Pooled it
- Receptor Specificity Engineering of TNF Superfamily Ligands.Pharmaceutics · 2022Review
- Chronic histiocytic intervillositis: A breakdown in immune tolerance comparable to allograft rejection?American journal of reproductive immunology (New York, N.Y. : 1989) · 2021Review
- Congenital Transmission of Apicomplexan Parasites: A Review.Frontiers in microbiology · 2021Review
- Upregulation of HLA-Class I and II in Placentas Diagnosed with Villitis of Unknown Etiology.Reproductive sciences (Thousand Oaks, Calif.) · 2020Article
- Placental Structure in Preterm Birth Among HIV-Positive Versus HIV-Negative Women in Kenya.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Failure of physiologic transformation of spiral arteries, endothelial and trophoblast cell activation, and acute atherosis in the basal plate of the placenta.American journal of obstetrics and gynecology · 2017Article
- Prolonged activation of innate antiviral gene signature after childbirth is determined by IFNL3 genotype.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The role of CX3CL1 in fetal-maternal interaction during human gestation.Cell adhesion & migration · 2016Review
- Chronic inflammation of the placenta: definition, classification, pathogenesis, and clinical significance.American journal of obstetrics and gynecology · 2015Review
- Placental fractalkine mediates adhesion of THP-1 monocytes to villous trophoblast.Histochemistry and cell biology · 2015Article
- Induction of pro-inflammatory response of the placental trophoblast by Plasmodium falciparum infected erythrocytes and TNF.Malaria journal · 2013Article
- Bi-directional calcium signaling between adjacent leukocytes and trophoblast-like cells.American journal of reproductive immunology (New York, N.Y. : 1989) · 2010Article
- Congenital toxoplasmosis: candidate host immune genes relevant for vertical transmission and pathogenesis.Genes and immunity · 2010Review
- Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta.Placenta · 2008Article
- Macrophage migration inhibitory factor is up-regulated in human first-trimester placenta stimulated by soluble antigen of Toxoplasma gondii, resulting in increased monocyte adhesion on villous explants.The American journal of pathology · 2008Article
- Invasion of the placenta during murine listeriosis.Infection and immunity · 2006Article
- Secretion of tumor necrosis factor-alpha from human placental tissues induced by hypoxia-reoxygenation causes endothelial cell activation in vitro: a potential mediator of the inflammatory response in preeclampsia.The American journal of pathology · 2004Article
- Role of NK cells and gamma interferon in transplacental passage of Toxoplasma gondii in a mouse model of primary infection.Infection and immunity · 2004Article
- Human cytomegalovirus-caused damage to placental trophoblasts mediated by immediate-early gene-induced tumor necrosis factor-alpha.The American journal of pathology · 2002Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulation of maternal monocytes in the villous/intervillous space (villitis) is associated with increased risk of perinatal morbidity and mortality and may initiate in utero transmission of cell-associated infectious agents such cytomegalovirus and HIV-1. We have developed an in vitro model of trophoblast syncytialization and have investigated the adhesive interactions between this tissue and peripheral blood monocytes. We show that monocytes strongly adhere to cultured syncytiotrophoblasts (STs) and that treatment with the inflammatory cytokines interferon-gamma, tumor necrosis factor-alpha, and interleukin-1 alpha greatly increase the number bound. Pretreatment of STs with these cytokines upregulated apical expression of intercellular cell adhesion molecule (ICAM)-1 but not E-or L-selection, ICAM-2 or -3, or various integrins. ICAM-1 expression was cytokine concentration dependent, significantly increased within 6 hours of treatment, peaked after 24 hours, and remained undiminished for 48 hours after cytokine removal from the cultures. Adhesion of monocytes to STs was inhibited > 80% by antibody to ICAM-1 or its cognate ligand LFA-1. ICAM-1 was detected immunohistochemically only in rare foci on intact term placental villi. These results suggest that villous trophoblast expression of ICAM-1 occurs only during an immune inflammatory reaction and that aberrant expression of this molecule may be an important pathological feature in those immunoinflammatory disorders of the placenta characterized by an excessive accumulation of leukocytes in the intervillous/villous space such as spontaneous abortion, perinatal hematogenous infections, and villitis of unknown etiology.
Indexed as
Identifiers
9137107PMC1858201W1522001954What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.