Evidence map›Paper›PMID 9137078›Full record

ArticleThe American journal of pathology1997

Platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) tyrosine phosphorylation state changes during vasculogenesis in the murine conceptus.

E Pinter, M Barreuther, T Lu, B A Imhof, J A Madri

Abstract read
In one paragraph

Article in The American journal of pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. A hydrogel-endothelial cell implant mimics infantile hemangioma: modulation by survivin and the Hippo pathway.Laboratory investigation; a journal of technical methods and pathology · 2015
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. The mouse aortocaval fistula recapitulates human arteriovenous fistula maturation.American journal of physiology. Heart and circulatory physiology · 2013
    Article
  11. Dynamic Regulation of Integrin αAdvances in wound care · 2013
    Article
  12. Article
  13. Article
  14. Role of HIF-1α in maternal hyperglycemia-induced embryonic vasculopathy.American journal of obstetrics and gynecology · 2011
    Article
  15. Article
  16. Vascular potential of human pluripotent stem cells.Arteriosclerosis, thrombosis, and vascular biology · 2010
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

E PinterDepartment of Pathology, Yale University School of Medicine, New Haven, CT 06520-8023, USA.
M Barreuther
T Lu
B A Imhof
J A Madri
Yale University · US

Funding

THE PATHOLOGY OF ENDOTHELIAL NEOVASCULIZATIONR01HL028373 · NHLBI · YALE UNIVERSITY · PI MADRI, JOSEPH A · 1985 to 1998
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NHLBI NIH HHS R01-HL-28373NHLBI NIH HHS R01-HL-28373-14SLPHS HHS P01-KD-38979
6 · The paper itself

Abstract

Vasculogenesis, the differentiation of mesodermal cells to angioblasts and the subsequent formation of blood islands and blood vessels by angioblasts in the conceptus, is a dynamic process modulated, in part, by cell-extracellular matrix and cell-cell interactions in the presence of a variety of growth factors and morphogens. In this report we demonstrate differential tyrosine phosphorylation of platelet-endothelial cell adhesion molecule-1 (PECAM-1) during the formation of blood islands and vessels from clusters of extraembryonic and embryonic angioblasts in the murine conceptus. In addition, we identify the phosphorylation of a particular tyrosine residue in the PECAM-1 cytoplasmic domain, Tyr686, which has the potential of mediating binding to Src homology 2 domain-containing proteins, affecting PECAM-1 cellular localization and endothelial cell migration.

Indexed as

Neovascularization, PhysiologicAnimalsAntibody SpecificityBlotting, WesternEmbryo, MammalianImmune SeraMicePhosphorylationPlatelet Endothelial Cell Adhesion Molecule-1Precipitin TestsTyrosineImmune SeraPlatelet Endothelial Cell Adhesion Molecule-1Tyrosine

Identifiers

PMID9137078
PMCPMC1858227
OpenAlexW348127839

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.