Evidence map›Paper›PMID 9135544›Full record

ArticleImmunology1997

Relationship between a low toxicity of the mutant A subunit of enterotoxigenic Escherichia coli enterotoxin and its strong adjuvant action.

T Tsuji, T Yokochi, H Kamiya, Y Kawamoto, A Miyama, Y Asano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 27 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

T TsujiDepartment of Microbiology, Fujita Health University, School of Medicine, Aichi, Japan.
T Yokochi
H Kamiya
Y Kawamoto
A Miyama
Y Asano
Czech Academy of Sciences, Institute of Microbiology · CZFujita Health University · JPAichi Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the work described here it was determined if and how unnicking in the A subunit of Escherichia coli enterotoxin at Arg192 or nearby residues affected biological activities of the toxin. The mutant toxin was constructed to lack the nick site in the A subunit by deleting the tripeptide Arg192-Thr193-Ile194, which is essential for toxicity. The mutant toxin did not exhibit agmatine ADP-ribosyltransferase activity in the presence or absence of the ADP-ribosylation factor and had less diarrhoeal activity and lower induction of cyclic AMP than did LT. The mutant toxin exhibited a much stronger adjuvant action on antibody responses to measles virus, keyhole limpt haemocyanin, bovine immunoglobulin and ovalbumin compared with LT. The altered toxicity of the mutant toxin might be closely related to the potent adjuvant action on antibody responses to antigens. The relationship between two activities is discussed.

Indexed as

Escherichia coli ProteinsAdjuvants, ImmunologicADP Ribose TransferasesAnimalsAntibodies, ViralBacterial ToxinsCyclic AMPDiarrheaElectrophoresis, Polyacrylamide GelEnterotoxinsEscherichia coliFemaleImmunoglobulin EImmunoglobulin GMeasles virusMiceAdjuvants, ImmunologicADP Ribose TransferasesAntibodies, ViralBacterial ToxinsCyclic AMPEnterotoxinsEscherichia coli Proteinsheat-labile enterotoxin, E coliImmunoglobulin EImmunoglobulin G

Identifiers

PMID9135544
PMCPMC1456747
OpenAlexW2084721524

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.