ArticleGut1997
Colonic muscle enhances the production of interleukin-1 beta messenger RNA in experimental colitis.
Article in Gut, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 44 citations in OpenAlex.
- Gut Region-Specific Interleukin 1β Induction in Different Myenteric Neuronal Subpopulations of Type 1 Diabetic Rats.International journal of molecular sciences · 2023Article
- Excessive dietary L-tryptophan regulated amino acids metabolism and serotonin signaling in the colon of weaning piglets with acetate-induced gut inflammation.Amino acids · 2023Article
- Immunological alteration and changes of gut microbiota after dextran sulfate sodium (DSS) administration in mice.Clinical and experimental medicine · 2015Article
- Expression of alternatively spliced variants of Na-Ca-exchanger-1 in experimental colitis: role in reduced colonic contractility.Molecular and cellular biochemistry · 2012Article
- Upregulation of RGS4 expression by IL-1beta in colonic smooth muscle is enhanced by ERK1/2 and p38 MAPK and inhibited by the PI3K/Akt/GSK3beta pathway.American journal of physiology. Cell physiology · 2009Article
- Upregulation of RGS4 and downregulation of CPI-17 mediate inhibition of colonic muscle contraction by interleukin-1beta.American journal of physiology. Cell physiology · 2007Article
- Mechanism of reduced colonic contractility in experimental colitis: role of sarcoplasmic reticulum pump isoform-2.Molecular and cellular biochemistry · 2007Article
- Expression and sub cellular localization of the sodium hydrogen exchanger isoform-1 in rat tissues: a possible functional relevance.Molecular and cellular biochemistry · 2001Article
- Blood purine and energy status in rats with colitis.Digestive diseases and sciences · 2001Article
- Altered expression of the Na+/H+ exchanger isoform-3 in experimental colitis: effect of garlic.Molecular and cellular biochemistry · 1999Article
- Molecular basis of altered contractility in experimental colitis: expression of L-type calcium channel.Digestive diseases and sciences · 1999Article
- Studies on purine enzymes in experimental colitis.Molecular and cellular biochemistry · 1999Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInflammatory bowel diseases are accompanied by alterations in the contractile function of colonic muscle. Whether these changes are also accompanied by the production of interleukin-1 beta (IL-1 beta) mRNA remains unknown.
aimsTo investigate the profile of IL-1 beta mRNA in the colonic muscle of rats with acetic acid induced colitis.
methodsColitis was induced by intrarectal administration of 1 ml of 4% acetic acid 8 cm from anal margin. Myeloperoxidase activity was used as a marker of inflammation in the colon. RNA was extracted from colonic muscle and was used to amplify the level of IL-1 beta mRNA with a reverse transcription coupled polymerase chain reaction (RT-PCR) method developed in this study.
resultsColonic muscle exhibited constitutive expression of IL-1 beta mRNA. The level was enhanced significantly, one, two, and five days after acetic acid administration. On day 7 after treatment, the level of IL-1 beta mRNA had returned baseline values. This profile of IL-1 beta mRNA was consistent with myeloperoxidase activity.
conclusionsIL-1 beta is a putative mediator of the changes in muscle function in this model of colitis.
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