Evidence map›Paper›PMID 9135288›Full record

Trial reportArchives of disease in childhood. Fetal and neonatal edition1997

Early administration of Bifidobacterium breve to preterm infants: randomised controlled trial.

H Kitajima, Y Sumida, R Tanaka, N Yuki, H Takayama, M Fujimura

Registry-linked trialAbstract readClinical TrialRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Archives of disease in childhood. Fetal and neonatal edition, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00616876 (The Effects of Lactulose Supplementation to Enteral Feedings in Premature Infants - A Pilot Study), which is not on this map. Cited by 92 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 20 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00616876 phase2completednot on this mapstarted 2005, after this paper: background citation

The Effects of Lactulose Supplementation to Enteral Feedings in Premature Infants - A Pilot Study

TypeinterventionalSponsorBnai Zion Medical CenterRan2005 to 2007Enrolled28ConditionsNecrotizing Enterocolitis, SepsisArmsLactulose, Dextrose
3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 20 syntheses or guidelines pooled it.

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  4. [Efficacy of probiotics in preventing late-onset sepsis in very low birth weight infants: a Meta analysis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021
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  17. A meta-analysis of probiotics for preventing necrotizing enterocolitis in preterm neonates.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014
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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

H KitajimaOsaka Medical Center, Japan.
Y Sumida
R Tanaka
N Yuki
H Takayama
M Fujimura

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the colonisation with Bifidobacterium breve of the bowels of very low birthweight (VLBW) infants.

methodsThe adverse effects of B breve were examined in 66 VLBW infants (preliminary study). A prospective randomised clinical study of 91 VLBW infants was also completed and these infants were followed up for three years. Precise viable bacterial counts of serial stool specimens were examined for the first eight weeks after birth in 10 infants. The colonisation rates of administered bacteria were examined using immunohistochemical staining of stool specimens with a B breve specific monoclonal antibody.

resultsIn the preliminary study there were no side effects attributable to the bacteria. Immunohistochemical staining of stool specimens showed that the colonisation rates of the administered bacteria were 73% at 2 weeks of age, but only 12% in the control group. Early administration of B breve significantly decreased aspirated air volume from the stomach and improved weight gain.

conclusionsB breve can colonise the immature bowel very effectively and is associated with fewer abnormal abdominal signs and better weight gain in VLBW infants, probably as a result of stabilisation of their intestinal flora and accelerated feeding schedules.

Indexed as

Infant, PrematureInfant, Very Low Birth WeightBifidobacteriumColony Count, MicrobialFecesFemaleFollow-Up StudiesHumansImmunohistochemistryInfant, NewbornIntestinesMaleWeight Gain

Identifiers

PMID9135288
PMCPMC1720633

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.