ArticleThe EMBO journal1997
Shared and distinct functions of RAGS and ELF-1 in guiding retinal axons.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
- Intracellular Trafficking Mechanisms that Regulate Repulsive Axon Guidance.Neuroscience · 2023Review
- Molecular complexity of visual mapping: a challenge for regenerating therapy.Neural regeneration research · 2020Review
- Inter-axonal recognition organizes Drosophila olfactory map formation.Scientific reports · 2019Article
- Reduction of ephrin-A5 aggravates disease progression in amyotrophic lateral sclerosis.Acta neuropathologica communications · 2019Article
- Wiring the Binocular Visual Pathways.International journal of molecular sciences · 2019Review
- The Mouse Superior Colliculus: An Emerging Model for Studying Circuit Formation and Function.Frontiers in neural circuits · 2018Review
- EphA4 has distinct functionality from EphA7 in the corticothalamic system during mouse brain development.The Journal of comparative neurology · 2016Article
- Rules for Shaping Neural Connections in the Developing Brain.Frontiers in neural circuits · 2016Review
- Quantitative assessment of computational models for retinotopic map formation.Developmental neurobiology · 2015Article
- Engrailed homeoproteins in visual system development.Cellular and molecular life sciences : CMLS · 2015Review
- Eph and ephrin signaling in the formation of topographic maps.Seminars in cell & developmental biology · 2012Review
- Article
- Competition is a driving force in topographic mapping.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Genetic dissection of EphA receptor signaling dynamics during retinotopic mapping.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Transcription factor Foxd1 is required for the specification of the temporal retina in mammals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Visual map development: bidirectional signaling, bifunctional guidance molecules, and competition.Cold Spring Harbor perspectives in biology · 2010Review
- EphrinA5 protein distribution in the developing mouse brain.BMC neuroscience · 2010Article
- Astrocyte-produced ephrins inhibit schwann cell migration via VAV2 signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Article
- Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors.The Journal of biological chemistry · 2008Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two ligands for Eph-related receptor tyrosine kinases, RAGS and ELF-1, have been implicated in the control of development of the retinotectal projection. Both molecules are expressed in overlapping gradients in the tectum, the target area of retinal ganglion cell axons. In two in vitro assays ELF-1 is shown to have a repellent axon guidance function for temporal, but apparently not for nasal axons. RAGS on the other hand is repellent for both types of axons, though to different degrees. Thus, RAGS and ELF-1 share some and differ in other properties. The biological activities of these molecules correlate with the strength of interaction with their receptors expressed on RGC axons. The meaning of these findings for guidance of retinal axons in the tectum is discussed.
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