ArticleThe EMBO journal1997
Receptor co-operation in retrovirus entry: recruitment of an auxiliary entry mechanism after retargeted binding.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Sequence Diversity, Intersubgroup Relationships, and Origins of the Mouse Leukemia Gammaretroviruses of Laboratory and Wild Mice.Journal of virology · 2016Article
- Phosphatidylserine treatment relieves the block to retrovirus infection of cells expressing glycosylated virus receptors.Retrovirology · 2005Article
- Targeted retroviral infection of tumor cells by receptor cooperation.Journal of virology · 2003Article
- Redirecting retroviral tropism by insertion of short, nondisruptive peptide ligands into envelope.Journal of virology · 2002Article
- Comprehensive mutational analysis of the Moloney murine leukemia virus envelope protein.Journal of virology · 2001Article
- Role of chimeric murine leukemia virus env beta-turn polyproline spacers in receptor cooperation.Journal of virology · 2001Article
- Receptors and entry cofactors for retroviruses include single and multiple transmembrane-spanning proteins as well as newly described glycophosphatidylinositol-anchored and secreted proteins.Microbiology and molecular biology reviews : MMBR · 2001Review
- Separable mechanisms of attachment and cell uptake during retrovirus infection.Journal of virology · 2000Article
- A TVA-single-chain antibody fusion protein mediates specific targeting of a subgroup A avian leukosis virus vector to cells expressing a tumor-specific form of epidermal growth factor receptor.Journal of virology · 2000Article
- Viral vectors for gene transfer: a review of their use in the treatment of human diseases.Drugs · 2000Review
- Activation of a cell entry pathway common to type C mammalian retroviruses by soluble envelope fragments.Journal of virology · 2000Article
- Retrovirus targeting by tropism restriction to melanoma cells.Journal of virology · 1999Article
- Identification of the block in targeted retroviral-mediated gene transfer.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- A proline-rich motif downstream of the receptor binding domain modulates conformation and fusogenicity of murine retroviral envelopes.Journal of virology · 1998Article
- Characterization of the proline-rich region of murine leukemia virus envelope protein.Journal of virology · 1998Article
- Changing viral tropism using immunoliposomes alters the stability of gene expression: implications for viral vector design.Molecular medicine (Cambridge, Mass.)Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have constructed Moloney murine leukemia virus (MoMLV)-derived envelope glycoproteins (AMO) displaying an amino-terminal Ram-1-binding domain in which a variety of different amino acid spacers have been inserted between the displayed domain and the MoMLV surface (SU) subunit. Titres of retroviruses generated with these chimeric envelopes were enhanced on cells expressing both Ram-1 and Rec-1 receptors compared with the titres on cells expressing only one or other receptor type. The absolute viral titres and the degree of titre enhancement due to receptor cooperativity were highly variable between the different chimeric envelopes and were determined primarily by the properties of the interdomain spacer. An extreme example of receptor co-operativity was encountered when testing Ram-1-targeted AMOPRO envelopes with specific proline-rich interdomain spacers. AMOPRO viruses could not enter cells expressing only Rec-1 or only Ram-1 but could efficiently infect cells co-expressing both receptors. The data are consistent with a model for receptor co-operativity in which binding to the targeted (Ram-1) receptor triggers conformational rearrangements of the envelope that lead to complete unmasking of the hidden Rec-1-binding domain, thereby facilitating its interaction with the viral (Rec-1) receptor which leads to optimal fusion triggering.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.