ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences1997
A discrete cell model with adaptive signalling for aggregation of Dictyostelium discoideum.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 128 citations in OpenAlex.
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- Review
- Eco-evolutionary significance of "loners".PLoS biology · 2020Article
- Multiscale phenomena and patterns in biological systems: special issue in honour of Hans Othmer.Journal of mathematical biology · 2020Article
- The role of intracellular signaling in the stripe formation in engineered Escherichia coli populations.PLoS computational biology · 2018Article
- Spatially extended hybrid methods: a review.Journal of the Royal Society, Interface · 2018Review
- Progress and perspectives in signal transduction, actin dynamics, and movement at the cell and tissue level: lessons fromInterface focus · 2016Review
- Collective Signal Processing in Cluster Chemotaxis: Roles of Adaptation, Amplification, and Co-attraction in Collective Guidance.PLoS computational biology · 2016Article
- Self-organization of chemoattractant waves in Dictyostelium depends on F-actin and cell-substrate adhesion.Journal of the Royal Society, Interface · 2016Article
- Macroscopic equations for bacterial chemotaxis: integration of detailed biochemistry of cell signaling.Journal of mathematical biology · 2015Article
- A hybrid model of tumor-stromal interactions in breast cancer.Bulletin of mathematical biology · 2013Article
- Modeling and measuring signal relay in noisy directed migration of cell groups.PLoS computational biology · 2013Article
- Diverse sensitivity thresholds in dynamic signaling responses by social amoebae.Science signaling · 2012Article
- Continuum limits of pattern formation in hexagonal-cell monolayers.Journal of mathematical biology · 2012Article
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2 authors at 1 institution in 1 country.
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Abstract
Dictyostelium discoideum (Dd) is a widely studied model system from which fundamental insights into cell movement, chemotaxis, aggregation and pattern formation can be gained. In this system aggregation results from the chemotactic response by dispersed amoebae to a travelling wave of the chemoattractant cAMP. We have developed a model in which the cells are treated as discrete points in a continuum field of the chemoattractant, and transduction of the extracellular cAMP signal into the intracellular signal is based on the G protein model developed by Tang & Othmer. The model reproduces a number of experimental observations and gives further insight into the aggregation process. We investigate different rules for cell movement the factors that influence stream formation the effect on aggregation of noise in the choice of the direction of movement and when spiral waves of chemoattractant and cell density are likely to occur. Our results give new insight into the origin of spiral waves and suggest that streaming is due to a finite amplitude instability.
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