ReviewJournal of bioenergetics and biomembranes1996
Is there VDAC in cell compartments other than the mitochondria?
Review in Journal of bioenergetics and biomembranes, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 54 citations in OpenAlex.
- VDAC1 regulates neuronal cell loss after retinal trauma injury by a mitochondria-independent pathway.Cell death & disease · 2022Article
- Targeting Mitochondrial Ion Channels to Fight Cancer.International journal of molecular sciences · 2018Review
- VDAC1: from structure to cancer therapy.Frontiers in oncology · 2012Article
- Identification of a mutated BHK-21 cell line that became less susceptible to Japanese encephalitis virus infection.Virology journal · 2011Article
- Article
- Comparative Bioinformatics Analyses and Profiling of Lysosome-Related Organelle Proteomes.International journal of mass spectrometry · 2007Article
- Biophysical properties of the apoptosis-inducing plasma membrane voltage-dependent anion channel.Biophysical journal · 2006Article
- On the role of VDAC in apoptosis: fact and fiction.Journal of bioenergetics and biomembranes · 2005Article
- The voltage-dependent anion channel in endoplasmic/sarcoplasmic reticulum: characterization, modulation and possible function.The Journal of membrane biology · 2005Review
- Voltage-dependent anion channel-1 (VDAC-1) contributes to ATP release and cell volume regulation in murine cells.The Journal of general physiology · 2004Article
- Evidence for secretory pathway localization of a voltage-dependent anion channel isoform.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Intracellular localization and isoform expression of the voltage-dependent anion channel (VDAC) in normal and dystrophic skeletal muscle.Journal of muscle research and cell motility · 2000Article
- Homologous and heterologous interactions between hexokinase and mitochondrial porin: evolutionary implications.Journal of bioenergetics and biomembranes · 1997Review
- Mitochondrial channels revisited.Journal of bioenergetics and biomembranes · 1996Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Higher eukaryotes, including mammals and plants, express a family of VDAC proteins each encoded by a distinct gene. Two human genes encoding VDAC isoforms (HVDAC1 and HVDAC2) have been characterized in greatest detail. These genes generate three proteins that differ primarily by the addition of distinct N terminal extensions in HVDAC2 and HVDAC2', a splice variant of HVDAC2, relative to HVDAC1. Since N terminal sequences have been demonstrated to target many proteins to appropriate subcellular compartments, this observation raises the possibility that the N terminal differences found in HVDAC isoforms may lead to targeting of each protein to different cellular locations. Consistent with this hypothesis, a large number of reports have provided evidence consistent with the notion that HVDAC1 and its homolog in related mammalian species may specifically be present in the plasma membrane or other nonmitochondrial cellular compartments. Here, we review this information and conclude that if VDAC molecules are present at nonmitochondrial locations in mammalian cells, these are unlikely to be the known products of the HVDAC1 or HVDAC2 genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.