ReviewJournal of bioenergetics and biomembranes1996
ATP-regulated K+ channel in mitochondria: pharmacology and function.
Review in Journal of bioenergetics and biomembranes, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 33 citations in OpenAlex.
- The iron chelator Deferasirox causes severe mitochondrial swelling without depolarization due to a specific effect on inner membrane permeability.Scientific reports · 2020Article
- Persistent mitoKMolecular neurobiology · 2017Article
- Single channel studies of the ATP-regulated potassium channel in brain mitochondria.Journal of bioenergetics and biomembranes · 2009Article
- Inhibition of mitochondrial membrane permeability as a putative pharmacological target for cardioprotection.Current medicinal chemistry · 2009Review
- Matrix volume measurements challenge the existence of diazoxide/glibencamide-sensitive KATP channels in rat mitochondria.The Journal of physiology · 2003Article
- Mitochondrial channels revisited.Journal of bioenergetics and biomembranes · 1996Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondria from several tissues contain a potassium-specific channel similar to the ATP-regulated K+ (K ATP) channel of the plasma membrane. The mitochondrial channel shares with the plasma membrane K ATP channel the sensitivity to sulfonylurea derivatives and some other blockers as well as to channel openers of diverse chemical character. In contrast to the plasma membrane channel, which is blocked by free ATP, the mitochondrial K ATP channel reconstituted into liposomes requires the ATP-Mg complex for inhibition. The mitochondrial K ATP channel, possibly in a concerted action with other K+ permeability pathways, plays an important role in mitochondrial volume control. Its function in the regulation of the components of the protonmotive force is also suggested.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.