ReviewJournal of bioenergetics and biomembranes1996
Perspectives on the mitochondrial multiple conductance channel.
Review in Journal of bioenergetics and biomembranes, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 66 citations in OpenAlex.
- Bedaquiline inhibits the ATP synthase leak channel and prevents glutamate-induced neuronal death.Biophysical reports · 2026Article
- Bedaquiline inhibits the ATP synthase leak channel and prevents glutamate-induced neuronal death.bioRxiv : the preprint server for biology · 2026Article
- Investigation of mitochondrial inner membrane ion conductance by planar lipid bilayer electrophysiology.Frontiers in physiology · 2026Article
- Investigation of Properties of the Mitochondrial Permeability Transition Pore Using Whole-Mitoplast Patch-Clamp Technique.DNA and cell biology · 2023Article
- ATP Synthase C-Subunit-Deficient Mitochondria Have a Small Cyclosporine A-Sensitive Channel, but Lack the Permeability Transition Pore.Cell reports · 2019Article
- The Mitochondrial Permeability Transition in Mitochondrial Disorders.Oxidative medicine and cellular longevity · 2019Review
- Revisiting trends on mitochondrial mega-channels for the import of proteins and nucleic acids.Journal of bioenergetics and biomembranes · 2017Review
- Electro-pharmacological profiles of two brain mitoplast anion channels: Inferences from single channel recording.EXCLI journal · 2017Article
- Role of polyhydroxybutyrate in mitochondrial calcium uptake.Cell calcium · 2013Article
- Physiologic functions of cyclophilin D and the mitochondrial permeability transition pore.Circulation journal : official journal of the Japanese Circulation Society · 2013Review
- The therapeutic potential of mitochondrial channels in cancer, ischemia-reperfusion injury, and neurodegeneration.Mitochondrion · 2012Review
- Inhibition of anion channels derived from mitochondrial membranes of the rat heart by stilbene disulfonate--DIDS.Journal of bioenergetics and biomembranes · 2007Article
- Comparison of the TIM and TOM channel activities of the mitochondrial protein import complexes.Biophysical journal · 2003Article
- Pathophysiological and protective roles of mitochondrial ion channels.The Journal of physiology · 2000Review
- Inositol 1,4,5-trisphosphate-induced Ca2+ release is inhibited by mitochondrial depolarization.The Biochemical journal · 2000Article
- MCC and PSC, the putative protein import channels of mitochondria.Journal of bioenergetics and biomembranes · 2000Review
- Effects of carbonyl cyanide phenylhydrazones on two mitochondrial ion channel activities.Journal of bioenergetics and biomembranes · 1997Article
- Tim23, a protein import component of the mitochondrial inner membrane, is required for normal activity of the multiple conductance channel, MCC.The Journal of cell biology · 1997Article
- The mitochondrial protein import pathway: are precursors imported through membrane channels?Journal of bioenergetics and biomembranes · 1997Review
- Mitochondrial channels revisited.Journal of bioenergetics and biomembranes · 1996Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A multiple conductance channel (MCC) with a peak conductance of over 1 nS is recorded from mitoplasts (mitochondria with the inner membrane exposed) using patch-clamp techniques. MCC shares many general characteristics with other intracellular megachannels, many of which are weakly selective, voltage-dependent, and calcium sensitive. A role in protein import is suggested by the transient blockade of MCC by peptides responsible for targeting mitochondrial precursor proteins. MCC is compared with the peptide-sensitive channel of the outer membrane because of similarities in targeting peptide blockade. The pharmacology and regulation of MCC by physiological effectors are reviewed and compared with the properties of the pore hypothesized to be responsible for the mitochondrial inner membrane permeability transition.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.