ArticleThe EMBO journal1997
Isolation of actin-associated proteins from Caenorhabditis elegans oocytes and their localization in the early embryo.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Extensive programmed centriole elimination unveiled inScience advances · 2023Article
- Actin filament debranching regulates cell polarity during cell migration and asymmetric cell division.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Caenorhabditis elegans sperm carry a histone-based epigenetic memory of both spermatogenesis and oogenesis.Nature communications · 2018Article
- The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics.Nature communications · 2014Article
- Global characterization of the oocyte-to-embryo transition in Caenorhabditis elegans uncovers a novel mRNA clearance mechanism.The EMBO journal · 2014Article
- Article
- Macro-level modeling of the response of C. elegans reproduction to chronic heat stress.PLoS computational biology · 2012Article
- The genetics and cell biology of fertilization.Methods in cell biology · 2011Review
- Actin complexes in the cell nucleus: new stones in an old field.Histochemistry and cell biology · 2010Review
- Diverse roles of actin in C. elegans early embryogenesis.BMC developmental biology · 2007Article
- Analysis of mid1p, a protein required for placement of the cell division site, reveals a link between the nucleus and the cell surface in fission yeast.Molecular biology of the cell · 2000Article
- The coronin-like protein POD-1 is required for anterior-posterior axis formation and cellular architecture in the nematode caenorhabditis elegans.Genes & development · 1999Article
- 2E4 (kaptin): a novel actin-associated protein from human blood platelets found in lamellipodia and the tips of the stereocilia of the inner ear.European journal of cell biology · 1999Article
- A genetic screen for temperature-sensitive cell-division mutants of Caenorhabditis elegans.Genetics · 1998Article
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5 authors.
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Abstract
The actin cytoskeleton plays an important, but poorly understood, role in the development of multicellular organisms. To help illuminate this role, we used actin filament affinity chromatography to isolate actin binding proteins from large quantities of Caenorhabditis elegans oocytes. To examine how these proteins might be involved in early development, we prepared antibodies against some of them and determined their distribution in fixed embryos. Three of these proteins co-localize with different subsets of the embryonic actin cytoskeleton. One co-localizes with actin to all cell cortices. The second oscillates between the nucleus and cortex in a cell-cycle-dependent manner. The third is asymmetrically enriched at the anterior cortex of one-cell embryos, showing a temporal and spatial localization suggestive of a function in generating developmental asymmetry. We conclude that biochemistry is a feasible and useful approach in the study of early C. elegans development, and that the embryonic actin cytoskeleton is regulated in a complex fashion in order to carry out multiple, simultaneous functions.
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