ArticleBiophysical journal1997
Inversely correlated cycles in speed and turning in an ameba: an oscillatory model of cell locomotion.
Article in Biophysical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Three-component contour dynamics model to simulate and analyze amoeboid cell motility in two dimensions.PloS one · 2024Article
- Spontaneous signal generation by an excitable system for cell migration.Frontiers in cell and developmental biology · 2024Review
- Discrete Modeling of Amoeboid Locomotion and Chemotaxis in Dictyostelium discoideum by Tracking Pseudopodium Growth Direction.Scientific reports · 2017Article
- Integrative analysis of T cell motility from multi-channel microscopy data using TIAM.Journal of immunological methods · 2015Article
- The IQGAP-related protein DGAP1 mediates signaling to the actin cytoskeleton as an effector and a sequestrator of Rac1 GTPases.Cellular and molecular life sciences : CMLS · 2014Article
- Modeling and measuring signal relay in noisy directed migration of cell groups.PLoS computational biology · 2013Article
- A stochastic description of Dictyostelium chemotaxis.PloS one · 2012Article
- 'Dicty dynamics': Dictyostelium motility as persistent random motion.Physical biology · 2011Article
- Denoising two-photon calcium imaging data.PloS one · 2011Article
- Bimodal analysis reveals a general scaling law governing nondirected and chemotactic cell motility.Biophysical journal · 2010Article
- Functional analysis of spontaneous cell movement under different physiological conditions.PloS one · 2008Article
- Cell motility as persistent random motion: theories from experiments.Biophysical journal · 2005Article
- Stochastic models for cell motion and taxis.Journal of mathematical biology · 2004Article
- Increased noise as an effect of haploinsufficiency of the tumor-suppressor gene neurofibromatosis type 1 in vitro.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
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Authors and funding
2 authors.
Funding
Abstract
Previous biophysical models of ameboid crawling have described cell movement in terms of a persistent random walk. Speed and orientation were treated in the latter model as independent and temporally homogeneous stochastic processes. We show here that, at least in the case of Dictyostelium discoideum, both speed control and reorientation processes involve a deterministic, periodic component. We also show that the processes are synchronized and negatively correlated, as was suggested by earlier findings. That is, increased turning correlates with periods of slow movement. Therefore, previous models are inconsistent with the behavior of cells. Using a heuristic approach, we have developed a mathematical model that describes the statistical properties of the cell's velocity and movement of its centroid. Our observations and the model are consistent with the phenomenological description of ameboid motility as a cyclic process of pseudopod extension and retraction.
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