ArticleBiophysical journal1997
Influence of network topology on the elasticity of the red blood cell membrane skeleton.
Article in Biophysical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- αI-spectrin represents evolutionary optimization of spectrin for red blood cell deformability.Biophysical journal · 2021Article
- Image-based model of the spectrin cytoskeleton for red blood cell simulation.PLoS computational biology · 2017Article
- The effect of a high frequency electromagnetic field in the microwave range on red blood cells.Scientific reports · 2017Article
- A novel strain energy relationship for red blood cell membrane skeleton based on spectrin stiffness and its application to micropipette deformation.Biomechanics and modeling in mechanobiology · 2016Article
- Stiffening of Red Blood Cells Induced by Cytoskeleton Disorders: A Joint Theory-Experiment Study.Biophysical journal · 2015Article
- Propagation of mechanical stress through the actin cytoskeleton toward focal adhesions: model and experiment.Biophysical journal · 2008Article
- A hybrid model for erythrocyte membrane: a single unit of protein network coupled with lipid bilayer.Biophysical journal · 2007Article
- Mechanical properties of the cell nucleus and the effect of emerin deficiency.Biophysical journal · 2006Article
- Spectrin-level modeling of the cytoskeleton and optical tweezers stretching of the erythrocyte.Biophysical journal · 2005Article
- A prestressed cable network model of the adherent cell cytoskeleton.Biophysical journal · 2003Article
- Deformation-enhanced fluctuations in the red cell skeleton with theoretical relations to elasticity, connectivity, and spectrin unfolding.Biophysical journal · 2001Article
- Direct measurement of the area expansion and shear moduli of the human red blood cell membrane skeleton.Biophysical journal · 2001Article
- Elasticity of the red cell membrane and its relation to hemolytic disorders: an optical tweezers study.Biophysical journal · 1999Article
- The deformation of spherical vesicles with permeable, constant-area membranes: application to the red blood cell.Biophysical journal · 1999Article
- Calculation of a Gap restoration in the membrane skeleton of the red blood cell: possible role for myosin II in local repair.Biophysical journal · 1999Article
- Simulations of the erythrocyte cytoskeleton at large deformation. I. Microscopic models.Biophysical journal · 1998Article
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4 authors.
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Abstract
A finite-element network model is used to investigate the influence of the topology of the red blood cell membrane skeleton on its macroscopic mechanical properties. Network topology is characterized by the number of spectrin oligomers per actin junction (phi a) and the number of spectrin dimers per self-association junction (phi s). If it is assumed that all associated spectrin is in tetrameric form, with six tetramers per actin junction (i.e., phi a = 6.0 and phi s = 2.0), then the topology of the skeleton may be modeled by a random Delaunay triangular network. Recent images of the RBC membrane skeleton suggest that the values for these topological parameters are in the range of 4.2 < phi a < 5.5 and 2.1 < phi s < 2.3. Model networks that simulate these realistic topologies exhibit values of the shear modulus that vary by more than an order of magnitude relative to triangular networks. This indicates that networks with relatively sparse nontriangular topologies may be needed to model the RBC membrane skeleton accurately. The model is also used to simulate skeletal alterations associated with hereditary spherocytosis and Southeast Asian ovalocytosis.
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