ArticleBiophysical journal1997
Desensitization and resensitization kinetics of glutamate receptor channels from Drosophila larval muscle.
Article in Biophysical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- The gating properties of Drosophila NMJ glutamate receptors and their dependence on Neto.The Journal of physiology · 2024Article
- The effects of doxapram and its potential interactions with K2P channels in experimental model preparations.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Article
- Neto proteins differentially modulate the gating properties ofbioRxiv : the preprint server for biology · 2024Article
- Versatile Endogenous Editing of GluRIIA inCells · 2024Article
- Local BMP signaling: A sensor for synaptic activity that balances synapse growth and function.Current topics in developmental biology · 2022Review
- Postsynaptic cAMP signalling regulates the antagonistic balance ofDevelopment (Cambridge, England) · 2020Article
- Complexin cooperates with Bruchpilot to tether synaptic vesicles to the active zone cytomatrix.The Journal of cell biology · 2019Article
- The Transmembrane Domain of Synaptobrevin Influences Neurotransmitter Flux through Synaptic Fusion Pores.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Functional reconstitution of Drosophila melanogaster NMJ glutamate receptors.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Quantitative super-resolution imaging of Bruchpilot distinguishes active zone states.Nature communications · 2014Article
- Physiological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica neurons.Journal of neurophysiology · 2011Article
- Extracellular protons reduce quantal content and prolong synaptic currents at the Drosophila larval neuromuscular junction.Journal of neurogenetics · 2011Article
- Article
- Effect of ambient extracellular glutamate on Drosophila glutamate receptor trafficking and function.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2009Article
- Nonvesicular release of glutamate by glial xCT transporters suppresses glutamate receptor clustering in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Discs-large (DLG) is clustered by presynaptic innervation and regulates postsynaptic glutamate receptor subunit composition in Drosophila.BMC biology · 2005Article
- Differential regulation of active zone density during long-term strengthening of Drosophila neuromuscular junctions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Neuroprotection at Drosophila synapses conferred by prior heat shock.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Glutamate receptor expression regulates quantal size and quantal content at the Drosophila neuromuscular junction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- A memory for extracellular Ca2+ by speeding recovery of P2X receptors from desensitization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
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2 authors.
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Abstract
Outside-out patches from wild-type Drosophila larval muscle were exposed to L-glutamate (glu) using a piezo-driven application system. Glu receptor channels opened and desensitized in response to rapid applications of 10 mM glu. Desensitization was fitted with an exponential function with a mean time constant of desensitization (tau d) of 15 ms in response to 10 mM glu. The tau d was concentration dependent and decreased to 6 ms (on average) with 0.7 mM glu and increased again to 12 ms (on average) in response to 0.5 mM glu. Desensitization in response to longer applications of glu was almost complete, but surprisingly, even a 1-ms pulse of 3 mM glu produced about 30% desensitization. In the presence of low glu concentrations, the response to a pulse was reduced and was about halved by preequilibration with 30 microM glu. Recovery from desensitization was not concentration dependent and was fitted with an exponential function with a mean time constant of 150 ms. During recovery the channels rarely opened. Kinetic schemes were fitted to these results, and a circular reaction scheme was found to fit the data best. An important feature of the scheme is desensitization from a lower ligated closed state. This allows substantial desensitization of synaptic receptor channels in response to quantal release of transmitter, in part without opening of the channels. Desensitization reduces the probability of the channels opening in response to a subsequent release for a period of time determined by the rate of recovery from desensitization and might serve as a form of molecular short-term memory.
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