ArticleBiophysical journal1997
Alteration of P-type calcium channel gating by the spider toxin omega-Aga-IVA.
Article in Biophysical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 81 citations in OpenAlex.
- Axon initial segment structure and function in health and disease.Physiological reviews · 2025Review
- State-Dependent Inhibition of Nav1.8 Sodium Channels by VX-150 and VX-548.Molecular pharmacology · 2024Article
- Structural basis for different ω-agatoxin IVA sensitivities of the P-type and Q-type CaCell research · 2024Article
- A tale of two calcium channels: structural pharmacology of Cav2.1 and Cav3.2.Cell research · 2024Article
- Neurotoxins Acting at Synaptic Sites: A Brief Review on Mechanisms and Clinical Applications.Toxins · 2022Review
- µ-Theraphotoxin Pn3a inhibition of CaeLife · 2022Article
- EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues.The Journal of general physiology · 2021Article
- The Molecular Basis of Toxins' Interactions with Intracellular Signaling via Discrete Portals.Toxins · 2017Review
- The first knockin mouse model of episodic ataxia type 2.Experimental neurology · 2014Article
- Article
- The interaction between mGluR1 and the calcium channel Cav₂.₁ preserves coupling in the presence of long Homer proteins.Neuropharmacology · 2013Article
- Peptide neurotoxins that affect voltage-gated calcium channels: a close-up on ω-agatoxins.Toxins · 2011Review
- Structure, function, and pharmacology of acid-sensing ion channels (ASICs): focus on ASIC1a.International journal of physiology, pathophysiology and pharmacology · 2010Article
- Compensatory regulation of Cav2.1 Ca2+ channels in cerebellar Purkinje neurons lacking parvalbumin and calbindin D-28k.Journal of neurophysiology · 2010Article
- Leftward shift in the voltage-dependence for Ca2+ currents activation induced by a new toxin from Phoneutria reidyi (Aranae, Ctenidae) venom.Cellular and molecular neurobiology · 2007Article
- Tarantula toxins interacting with voltage sensors in potassium channels.Toxicon : official journal of the International Society on Toxinology · 2007Review
- Developmental activation of calmodulin-dependent facilitation of cerebellar P-type Ca2+ current.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- The tarantula toxin psalmotoxin 1 inhibits acid-sensing ion channel (ASIC) 1a by increasing its apparent H+ affinity.The Journal of general physiology · 2005Article
- Molecular surface of tarantula toxins interacting with voltage sensors in K(v) channels.The Journal of general physiology · 2004Article
- Molecular pharmacology of high voltage-activated calcium channels.Journal of bioenergetics and biomembranes · 2003Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We studied the mechanism of inhibition of P-type calcium channels in rat cerebellar Purkinje neurons by the peptide toxin omega-Aga-IVA. Saturating concentrations of omega-Aga-IVA (> 50 nM) inhibited inward current carried by 2-5 mM Ba almost completely. However, outward current at depolarizations of > +60 mV, carried by internal Cs, was inhibited much less, as was the tail current after such depolarizations. omega-Aga-IVA shifted the midpoint of the tail current activation curve by about +50 mV and made the curve less steep. The inactivation curve was also shifted in the depolarized direction and was made less steep. With omega-Aga-IVA, channels activated more slowly and deactivated more quickly than in control. Trains of repeated large depolarizations relieved the inhibition of current (as tested with moderate depolarizations), probably reflecting the unbinding of toxin. The relief of inhibition was faster with increasing depolarization, but did not require internal permeant ions. We conclude that omega-Aga-IVA alters voltage-dependent gating by stabilizing closed states of the channel and that omega-Aga-IVA dissociates much more rapidly from open channels than from closed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.